{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:57:52Z","timestamp":1793131072813,"version":"4.5.0"},"reference-count":68,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1212100"],"award-info":[{"award-number":["2024YFA1212100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017380","name":"Science and Technology Foundation of Shenzhen City","doi-asserted-by":"publisher","award":["JCYJ20241202124423032 20220809130438001"],"award-info":[{"award-number":["JCYJ20241202124423032 20220809130438001"]}],"id":[{"id":"10.13039\/100017380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52122317"],"award-info":[{"award-number":["52122317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bladder cancer is a common urological malignancy characterized by high morbidity, high recurrence rate and high mortality, imposing heavy burdens on patients mentally and financially. The research pioneers a diagnostic and therapeutic approach that integrates a second near\u2010infrared (NIR\u2010II) multimodal phototheranostic platform with optical fiber\u2010mediated interventional phototherapy strategy, to implement a comprehensive diagnosis and \u201cinside\u2010out\u201d treatment of bladder cancer. The proposed molecule, namely BTO\u2010TTQ, is elaborately designed through electron donor\/\u03c0\u2010bridge engineering and demonstrates satisfying NIR\u2010II emission with aggregation\u2010induced emission features, high photothermal conversion efficiency, and prominent generation of type I reactive oxygen species. Quantum chemical calculations and molecular dynamics simulations are employed to deeply elucidate the energy dissipation pathways of the excited state and the impact of intramolecular motion on their photophysical properties. Furthermore, under the guidance of NIR\u2010II fluorescent\u2010photoacoustic\u2010photothermal trimodal imaging, hyaluronic acid\u2010modified BTO\u2010TTQ nanoparticles exhibit exceptional performance in optical fiber\u2010mediated interventional phototherapy for air\u2010pouch bladder cancer models. This study thus brings a new insight into the development of superior versatile phototheranostics for clinical theranostics of bladder cancer.<\/jats:p>","DOI":"10.1002\/adma.202502452","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T06:10:58Z","timestamp":1746771058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Icing on the Cake: Integrating Optical Fiber with Second Near\u2010Infrared Aggregation\u2010Induced Emission Luminogen for Exceptional Phototheranostics of Bladder Cancer"],"prefix":"10.1002","volume":"37","author":[{"given":"Jun","family":"Zhu","sequence":"first","affiliation":[{"name":"Center for AIE Research Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Provincial Key Laboratory of New Energy Materials Service Safety College of Materials Science and Engineering Shenzhen University  Shenzhen 518060 China"},{"name":"College of Physics and Optoelectronic Engineering Shenzhen University  Shenzhen 518060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology The Fourth Affiliated Hospital of Soochow University Medical Center of Soochow University Suzhou Dushu Lake Hospital  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for AIE Research Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Provincial Key Laboratory of New Energy Materials Service Safety College of Materials Science and Engineering Shenzhen University  Shenzhen 518060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Soochow University  Suzhou 215006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianquan","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Urology The Fourth Affiliated Hospital of Soochow University Medical Center of Soochow University Suzhou Dushu Lake Hospital  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben Zhong","family":"Tang","sequence":"additional","affiliation":[{"name":"Center for AIE Research Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Provincial Key Laboratory of New Energy Materials Service Safety College of Materials Science and Engineering Shenzhen University  Shenzhen 518060 China"},{"name":"School of Science and Engineering Guangdong Basic Research Center of Excellence for Aggregate Science Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong  Shenzhen (CUHK\u2010Shenzhen) Guangdong 518172 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-0771","authenticated-orcid":false,"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for AIE Research Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Provincial Key Laboratory of New Energy Materials Service Safety College of Materials Science and Engineering Shenzhen University  Shenzhen 518060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.03.029"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.10.024"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103577"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.09.057"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2014.245"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-019-0184-4"},{"key":"e_1_2_7_5_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.06.037"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00671H"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201706320"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.708"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.419"},{"key":"e_1_2_7_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.699"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202003382"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00258"},{"key":"e_1_2_7_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805919"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b21299"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2986"},{"key":"e_1_2_7_9_3","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b12167"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c15150"},{"key":"e_1_2_7_10_2","volume":"63","author":"Li J.","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"e_1_2_7_10_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202401877"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6NR03656B"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202202614"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008292"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00234G"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00862G"},{"key":"e_1_2_7_13_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801778"},{"key":"e_1_2_7_13_4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202007040"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0071142"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c01349"},{"key":"e_1_2_7_14_3","doi-asserted-by":"publisher","DOI":"10.1002\/adom.202100859"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25391-z"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202200456"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201700448"},{"key":"e_1_2_7_16_3","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.413"},{"key":"e_1_2_7_16_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0581-x"},{"key":"e_1_2_7_16_5","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202410142"},{"key":"e_1_2_7_16_6","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202406474"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41377-024-01586-z"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.152495"},{"key":"e_1_2_7_17_3","doi-asserted-by":"publisher","DOI":"10.1002\/smsc.202400450"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14122996"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27030731"},{"key":"e_1_2_7_18_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2018.08.005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c04303"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.08.019"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c10770"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120755"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c10076"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2022.06.030"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202202614"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31521-y"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202410441"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b02452"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4TC03028A"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202000226"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physrep.2013.12.002"},{"key":"e_1_2_7_27_3","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nww024"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201810326"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201706945"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201601902"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios12090722"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202306699"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.06.036"},{"key":"e_1_2_7_32_3","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-18-0212"},{"key":"e_1_2_7_32_4","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210732"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202502452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:03:34Z","timestamp":1759770214000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202502452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":68,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/adma.202502452"],"URL":"https:\/\/doi.org\/10.1002\/adma.202502452","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,9]]},"assertion":[{"value":"2025-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2502452"}}