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However, no commercial bone adhesives exhibit high adhesion, strength, and osteogenic activity for instant and sustainable fixation in dynamic, wet humoral environments at weight\u2010bearing sites. Here, phase engineering is employed to construct a homogeneous hard\u2010soft biphasic bone adhesive (HB\u2010PTN) with a sea urchin\u2010inspired structure of phosphorylated polyglutamic acid (P\u2010PGA) encapsulating tetracalcium phosphate (TTCP) (hard phase) and a viscoelastic hydrogel composed of amino\u2010functionalized PEGylated poly (glycerol sebacate) (PEGS\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    ) and P\u2010PGA (soft phases) for immediate, stable fixation. The adhesion and strength of the HB\u2010PTN hydrogel can be tuned by modulating the soft phase\/hard phase ratio. The PTN\u20102 hydrogel exhibited an adhesive strength of \u2248280 kPa, a compressive modulus of \u22481.02 MPa, and high fatigue resistance (92%). Moreover, the PTN\u20102 hydrogel showed limited swelling (130%) and maintained mechanical properties (102%) after immersion in simulated human body fluid. Furthermore, this strategy avoids the agglomeration of inorganic particles and the formation of cracks due to stress concentration observed with traditional mixing methods. In vivo, the PTN adhesives reveal durable and stable adhesion and accelerate fracture healing, demonstrating great clinical potential in comminuted fracture repair.\n                  <\/jats:p>","DOI":"10.1002\/adma.202502598","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T06:49:07Z","timestamp":1749797347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Homogeneous \u201cHard\u2010Soft\u201d Biphasic Bone Adhesives Promote Comminuted Fracture Healing through Interfacial Adaptation and Mechanical Property Maintenance"],"prefix":"10.1002","volume":"37","author":[{"given":"Chuanwei","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 P. R. 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