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To address these, biomimetic bacterial outer membrane nanoparticles (BM\u2010NPs) are designed by integrating the precise targeting capability of detoxified outer membrane vesicles (dOMVs) with the efficient drug\u2010loading properties of liposomes. BM\u2010NPs exhibit superior targeting efficiency toward peripheral neutrophils and macrophages, enabling spatiotemporal drug delivery via immune cells. An innovative \u201cTortoise and Hare\u201d dynamic adaptive delivery strategy is introduced, where neutrophils facilitate rapid drug transport during the acute phase of SCI, while macrophages ensure sustained delivery during the subacute phase. This strategy aligns with the dynamic pathological progression of SCI, offering precision targeting tailored to different stages of injury. BM\u2010NPs demonstrate multifaceted therapeutic effects, including the suppression of foam cell formation through coordinated enhancement of lipid droplet autophagy and cholesterol efflux. Furthermore, they modulate the inflammatory microenvironment, preserve myelin integrity, and significantly promote neural functional recovery post\u2010SCI. By overcoming the limitations of conventional delivery systems in targeting and timeliness, BM\u2010NPs offer an innovative, highly efficient, and clinically translatable platform for SCI treatment and other acute inflammatory disorders of the central nervous system.<\/jats:p>","DOI":"10.1002\/adma.202502795","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:33:21Z","timestamp":1747726401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Spatiotemporal Targeted Delivery of Biomimetic Bacterial Outer Membrane Nanoparticles for Enhanced Spinal Cord Injury Repair"],"prefix":"10.1002","volume":"37","author":[{"given":"Pengfei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery The First Affiliated Hospital of Harbin Medical University Harbin Medical University  Harbin 150000 P. R. 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