{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:58:57Z","timestamp":1792843137349,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22374029"],"award-info":[{"award-number":["22374029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22174024"],"award-info":[{"award-number":["22174024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["23ZR1403200"],"award-info":[{"award-number":["23ZR1403200"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015789","name":"Dalian High-Level Talent Innovation Program","doi-asserted-by":"publisher","award":["QWH1615018"],"award-info":[{"award-number":["QWH1615018"]}],"id":[{"id":"10.13039\/100015789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Advancing clinical diagnostics requires platforms that combine catalytic efficiency, biocompatibility, and real\u2010time, in vivo accessibility. Herein, this study reports a structurally integrated FePc\u2013ZIF\u20108\u2013MX nanozyme that combines the redox activity of FePc, the porous confinement of ZIF\u20108, and the electrical conductivity of MX. Synthesized via a low\u2010energy, ambient\u2010condition process, this hybrid enables efficient electron transfer, enhanced analyte enrichment, and sustained catalytic activity in physiological environments. To translate this functionality into a wearable diagnostic format, the hybrid is seamlessly incorporated into a microneedle array, offering minimally invasive access to interstitial fluid for continuous L\u2010cysteine (L\u2010Cys) monitoring. The resulting platform exhibits high selectivity and sensitivity across complex biological matrices, including serum, urine, cultured cells, and a murine model of myocardial infarction. This study presents a multifunctional electrochemical platform that enables on\u2010body metabolite monitoring through a microneedle\u2010integrated nanozyme interface. To the best of our knowledge, it constitutes the first realization of real\u2010time, in vivo L\u2010Cys sensing in this format, setting a new benchmark for precision biosensing in translational healthcare.<\/jats:p>","DOI":"10.1002\/adma.202502804","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T03:13:48Z","timestamp":1747970028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Microneedle\u2010Integrated FePc\u2013MOF\u2013MXene Nanozyme Patch for In Vivo L\u2010Cysteine Monitoring"],"prefix":"10.1002","volume":"37","author":[{"given":"Ghazala","family":"Ashraf","sequence":"first","affiliation":[{"name":"Department of Chemistry Fudan University  Shanghai 200433 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Fudan University  Shanghai 200433 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Ahmed","sequence":"additional","affiliation":[{"name":"College of Civil Engineering Tongji University  Shanghai 200092 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Chemistry Fudan University  Shanghai 200433 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilie","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Chemistry Fudan University  Shanghai 200433 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-7868","authenticated-orcid":false,"given":"Xueen","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Fudan University  Shanghai 200433 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/aesr.202000102"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoms.2022.07.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c20645"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2022.101119"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.2c03058"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.34133\/energymatadv.0033"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2018.10.038"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2025.118208"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2019.100509"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01288-w"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202404350"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201601133"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2024.117857"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114188"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sintl.2022.100166"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b10302"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18062-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.138588"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.140634"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2020.10.096"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.135985"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2022.123314"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.138486"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0573-0"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.128133"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301045"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40580-024-00437-2"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-023-00108-7"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201604311"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201701264"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c06728"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2021.120064"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b00030"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2024.145110"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.7b02847"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.0c00359"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpca.5b08626"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.desal.2022.116184"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202110267"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214518"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpowsour.2020.228472"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202213106"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2023.134366"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202102495"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2009.03.008"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2019.03.205"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac5039863"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114129"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202000936"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c04224"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0002-3"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.e17504"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-009-9978-z"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1818"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201102306"},{"key":"e_1_2_8_56_1","volume":"11","author":"Gurz\u0119da B.","year":"2024","journal-title":"Adv. Mater."},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202309089"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46215-w"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202502804","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202502804","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202502804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T22:14:24Z","timestamp":1785968064000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202502804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":58,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/adma.202502804"],"URL":"https:\/\/doi.org\/10.1002\/adma.202502804","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,23]]},"assertion":[{"value":"2025-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2502804"}}