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However, a major challenge in SDT is the efficiency of ROS generation, particularly in the context of hypoxia within the tumor microenvironment. Herein, inspired by the natural peroxidase, an imide\u2010linked metal\u2010phthalocyanine\u2010based conjugated organic polymer (COP) (COP\n                    <jats:sub>TPcFe<\/jats:sub>\n                    ) has been designed with a well\u2010defined \u03c0\u2010conjugated nanostructure and peroxidase\u2010mimetic atomic Fe\u2010N sites for sonochemodynamic immunotherapy against neuroblastoma. This work demonstrates that COP\n                    <jats:sub>TPcFe<\/jats:sub>\n                    can efficiently produce potent ROS (\u2022OH and \u2022O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) by utilizing localized H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and the effects of ultrasound, thereby achieving efficient and synergistic tumoricidal activity. Notably, the highly \u03c0\u2010conjugated structure endows COP\n                    <jats:sub>TPcFe<\/jats:sub>\n                    with excellent electron transport capabilities, enabling rapid catalysis of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    to O\n                    <jats:sub>2<\/jats:sub>\n                    , thus alleviating the hypoxic conditions within tumors. Moreover, by encapsulating COP\n                    <jats:sub>TPcFe<\/jats:sub>\n                    with neuroblastoma cell membranes, this study achieveshomologous targeting of tumor cells and tissues, leading to efficient accumulation within tumor cells, mitochondrial disruption, and apoptosis. Additionally, the proposed sonochemodynamic immunotherapy effectively activates natural killer cells and reverses the immunosuppressive tumor microenvironment, thereby alleviating hypoxia and significantly enhancing the therapeutic efficacy of neuroblastoma treatment.\n                  <\/jats:p>","DOI":"10.1002\/adma.202503261","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T05:06:17Z","timestamp":1748581577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Neuroblastoma\u2010Targeting \u03c0\u2010Conjugated COP Nanostructure with Multiple Enzyme\u2010Mimetic Actions for Sonochemodynamic Immunotherapies"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3328-1147","authenticated-orcid":false,"given":"Qian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasound, West China Second University Hospital\/West China 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