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Autograft has been commonly utilized as the clinical gold standard; however, it is limited by donor availability and secondary surgery requirements. Here, an ultrasound\u2010responsive, highly aligned piezoelectric nanofiber nerve guidance conduit (APNF\u2010NGC) is introduced for peripheral nerve regeneration. Fabricated from electrospun poly\u2010\n                    <jats:italic>l<\/jats:italic>\n                    \u2010lactic acid (PLLA) nanofibers, the APNF\u2010NGC features an anisotropically oriented architecture with shear piezoelectricity, providing both structural support and wireless electrical stimulation. The incorporation of polyethylene glycol (PEG) tailors mechanical properties, increases piezoelectric\u2010phase crystallinity, and improves the surface hydrophilicity, thereby enhancing both biocompatibility and acousto\u2010piezoelectric response. Finite element analysis and electrical assessment confirm that ultrasound activation of the APNF\u2010NGC generates an axially oriented electric field, facilitating directional axon elongation. In vivo studies using an 8\u2010mm sciatic nerve defect rat model demonstrated that the APNF\u2010NGC achieved nerve reinnervation comparable to that of autografts, as comprehensively validated by behavioral, motor function, and histological evaluations. This dual\u2010function platform, combining physical guidance with electrical stimulation, presents a promising strategy for neural tissue engineering, offers a potential breakthrough in treating long\u2010gap PNIs.\n                  <\/jats:p>","DOI":"10.1002\/adma.202503343","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T06:31:03Z","timestamp":1756881063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Wireless Acousto\u2010Piezoelectric Conduit with Aligned Nanofibers for Neural Regeneration"],"prefix":"10.1002","volume":"37","author":[{"given":"Sera","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering Center for Human\u2010oriented Triboelectric Energy Harvesting Yonsei University  Seoul 03722 Republic of 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