{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:14:14Z","timestamp":1793294054212,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373155"],"award-info":[{"award-number":["52373155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173136"],"award-info":[{"award-number":["52173136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52131302"],"award-info":[{"award-number":["52131302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22135005"],"award-info":[{"award-number":["22135005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52333004"],"award-info":[{"award-number":["52333004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Gut\u2010associated lymphoid tissue (GALT) possesses a highly specialized immune system and is rational as a foothold for oral tumor vaccines. Here, a noninvasive oral vaccine (Bif\u2010OVA\u2010Ocur) is designed to engage GALT, inducing both intestinal mucosal and systemic immunity for tumor therapeutics. The vaccine uses\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    (Bif) as a delivery vehicle for tumor antigen peptides, which are coated with antigen peptides (OVA) and oxidized curdlan (Ocur) in a layer\u2010by\u2010layer (LBL) manner. Upon oral administration, Bif\u2010OVA\u2010Ocur is efficiently directed to Peyer's patches (PPs) in the intestines and further presented to antigen\u2010presenting cells (APCs), which then migrate to the mesenteric lymph nodes (MLNs) to evoke specific T cell responses. In mouse models, Bif\u2010OVA\u2010Ocur effectively boosts the production of secretory immunoglobin A (SIgA) and promotes a strong mucosal and systemic immune response, leading to significant tumor suppression and resistance to tumor challenges. Importantly, the vaccine shows no systemic toxicity. This approach to harnessing the intestinal mucosal immune system offers valuable insights for the development of other non\u2010invasive oral vaccines and therapeutic agents.\n                  <\/jats:p>","DOI":"10.1002\/adma.202503571","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T04:02:00Z","timestamp":1746504120000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Layer\u2010by\u2010Layer Deposition of Antigen Peptides on\n                    <i>Bifidobacterium<\/i>\n                    for Subintestinal Lymphatic System\u2010Guided Personalized Tumor Immunotherapy"],"prefix":"10.1002","volume":"37","author":[{"given":"Zhu","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University  Wuhan 430072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Teng","family":"Qin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University  Wuhan 430072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian\u2010Ru","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University  Wuhan 430072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Lian","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University  Wuhan 430072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Chen","family":"Deng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University  Wuhan 430072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University  Wuhan 430072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Dong","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University  Wuhan 430072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University  Wuhan 430072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Xia","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University  Wuhan 430072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-6005","authenticated-orcid":false,"given":"Xian\u2010Zheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University  Wuhan 430072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.035"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3251"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-02824-3"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06809-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c03419"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1439"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1213"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1038\/nri1777"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201903847"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adn7786"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202104139"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060227"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00389-4"},{"key":"e_1_2_8_9_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00448-w"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00583-2"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15221"},{"key":"e_1_2_8_10_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-024-01722-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-023-00625-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.04.008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00647B"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-00781-4"},{"key":"e_1_2_8_13_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-018-0028-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0181-y"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf0677"},{"key":"e_1_2_8_14_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.011"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00886-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar6918"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01346-x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-023-00119-4"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-024-00908-9"},{"key":"e_1_2_8_18_3","first-page":"550","volume":"54","author":"Chen H.\u2010H.","year":"2023","journal-title":"Acta Polym. Sin."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31171-0"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202100701"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2009.08.005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01553-6"},{"key":"e_1_2_8_22_2","first-page":"534","volume":"54","author":"Zhu Z.","year":"2023","journal-title":"Acta Polym. Sin."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08033-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201713075"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.07.003"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00506-1"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3322"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2886-4"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18847"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-024-01764-5"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51534-z"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00663-1"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01075-5"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202503571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202503571","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202503571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:38:16Z","timestamp":1775644696000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202503571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,6]]},"references-count":48,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/adma.202503571"],"URL":"https:\/\/doi.org\/10.1002\/adma.202503571","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,6]]},"assertion":[{"value":"2025-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2503571"}}