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The development of PTT and PDT is impeded by the limited tissue penetration depth of the light source. SDT is a promising method due to the deeper tissue penetration and site\u2010specific features of ultrasound; however, the scarcity of efficient sonosensitizers has constrained its clinical use. Herein, ultrasound\u2010triggered nanoparticles (NPs), named Ir\u20104@S\u2010R NPs, achieve a sonodynamic thrombolytic, bioorthogonal sonocatalytic reaction, with chemiluminescence (CL) imaging in the thrombus. An Ir(III) complex, named Ir\u20104, which has aggregation induced emission (AIE), combined with a hydrogen sulfide donor, named H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010N\n                    <jats:sub>3<\/jats:sub>\n                    , provide the nanoplatform which is modified with the peptide c(RGDfC) to target the thrombus. This supramolecular assembly successfully integrates: i) thrombosis detection based on near\u2010infrared (NIR) chemiluminescence imaging, ii) sonodynamic thrombus therapy and iii) release of hydrogen sulfide for anti\u2010inflammatory action. Ir\u20104@S\u2010R NPs emit long\u2010lasting NIR CL triggered by endogenous ONOO\n                    <jats:sup>\u2212<\/jats:sup>\n                    and achieve 12\u00a0mm deep tissue penetration. Blood clots are effectively removed and blood flow is almost fully restored in mouse carotid thrombus and rat femoral vein models. The work demonstrates a new integrated strategy for diagnosing and treating life\u2010threatening diseases caused by thrombusotic disorders.\n                  <\/jats:p>","DOI":"10.1002\/adma.202503599","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T06:57:47Z","timestamp":1752217067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Sonodynamic and Bioorthogonal Sonocatalytic Thrombotic Therapy Based on AIE Cationic Tetranuclear Ir(III) Complex Nanoplatform Guided by NIR\u2010Chemiluminescence Imaging"],"prefix":"10.1002","volume":"37","author":[{"given":"Zihan","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province Department of Chemistry Northeast Normal University  5268 Renmin Street Changchun Jilin Province 130024 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