{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:13:57Z","timestamp":1791558837206,"version":"4.3.4"},"reference-count":61,"publisher":"Wiley","issue":"28","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2408200"],"award-info":[{"award-number":["2022YFC2408200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.52221006"],"award-info":[{"award-number":["No.52221006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073014"],"award-info":[{"award-number":["52073014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["buctrc202020"],"award-info":[{"award-number":["buctrc202020"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Spinal cord injury (SCI) is a debilitating condition that leads to severe disabilities and imposes significant economic and social burdens. Current therapeutic strategies primarily focus on symptom management, with limited success in promoting full neurological recovery. In response to this challenge, the design of novel guidance conduits incorporating multiple gradient cues, inspired is reported by biological processes, to enhance spinal cord repair. These conduits are fabricated using electrospinning and masked coaxial electrospraying, a simple yet effective method that integrates topological, haptotactic, and chemotactic cues into a single scaffold. The synergy of these cues significantly promoted cell migration, neural stem cell differentiation into neurons, and axonal extension, resulting in substantial improvements in spinal cord regeneration and functional recovery in a rat model. Single\u2010nucleus RNA sequencing further demonstrated that the guidance conduit inhibited fibroblast proliferation, preserved microglial homeostasis, restored cellular proportions, and facilitated the regeneration of neuronal axons, dendrites, and synapses. This work presents an innovative, versatile platform for fabricating tissue scaffolds that integrate multiple gradient cues, offering a promising strategy for SCI treatment and broader tissue regeneration applications.<\/jats:p>","DOI":"10.1002\/adma.202503892","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T03:55:32Z","timestamp":1745898932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nanofibrous Guidance Conduits with Multiple Gradient Cues for Spinal Cord Repair"],"prefix":"10.1002","volume":"37","author":[{"given":"Xindan","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 P. R. China"},{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Guo","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing 100730 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing 100730 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xiong","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 P. R. China"},{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehao","family":"Yao","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 P. R. China"},{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Lin","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 P. R. China"},{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Hu","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 P. R. China"},{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 P. R. China"},{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Tian","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 P. R. China"},{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 P. R. China"},{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglai","family":"Lu","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 P. R. China"},{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiliang","family":"Zhai","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing 100730 P. R. China"},{"name":"Department of Orthopaedic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College  Beijing 100730 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Lu","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 P. R. China"},{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-7935","authenticated-orcid":false,"given":"Jiajia","family":"Xue","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 P. R. China"},{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing University of Chemical Technology  Beijing 100029 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"683","volume":"30","author":"Yousefifard M.","year":"2019","journal-title":"J. Neurosurg."},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0649-2"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05385-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06094-5"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01663-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00885-4"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01477-6"},{"key":"e_1_2_8_4_3","doi-asserted-by":"publisher","DOI":"10.7150\/thno.84133"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210035"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40242-021-1162-y"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202100061"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368917X695038"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade8829"},{"key":"e_1_2_8_6_3","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado9120"},{"key":"e_1_2_8_6_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120971"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121192"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA10385F"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204528"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg0234"},{"key":"e_1_2_8_8_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121190"},{"key":"e_1_2_8_8_4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00593"},{"key":"e_1_2_8_8_5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00218"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00654"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-022-01294-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppsc.202100280"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202002031"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.5058083"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202000735"},{"key":"e_1_2_8_11_3","doi-asserted-by":"publisher","DOI":"10.1021\/accountsmr.4c00186"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202002593"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b00129"},{"key":"e_1_2_8_12_3","doi-asserted-by":"publisher","DOI":"10.1021\/nl901582f"},{"key":"e_1_2_8_12_4","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202110628"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092053"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3897"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13854-3"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804735115"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7TB00974G"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2014.08.002"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/am405418g"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203296"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2019.0122"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.966866"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-99-6948-7_7"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00366-6"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304896"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/08977150260338038"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207533"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00795-0"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.02.003"},{"key":"e_1_2_8_25_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07504-y"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200337R"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210040"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40513-5"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110158"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1995.12.1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096801"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.987344"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.720271"},{"key":"e_1_2_8_30_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam8999"},{"key":"e_1_2_8_30_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.008"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202503892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202503892","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202503892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T06:43:59Z","timestamp":1773989039000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202503892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":61,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/adma.202503892"],"URL":"https:\/\/doi.org\/10.1002\/adma.202503892","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"assertion":[{"value":"2025-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2503892"}}