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Herein, a new DNA logical processing strategy is explored for selective cell engineering and to develop a feasible technology for precise cell identification. Specifically, this cell identification technology accomplishes logical engineering through the employment of cell surface\u2010confined DNAzyme coordination, which not only enables the labeling of versatile DNA probes at specific cells but also avoids false\u2010positive outputs caused by the neighboring non\u2010target cells. In proof\u2010of\u2010principle studies, this cell identification technology achieves precise magnetic isolation and electrochemical determination of specific cancer cells (i.e., stem cell\u2010like subpopulations in breast cancer). When further applied to tumors taken from mouse models, this technology exhibits accuracy comparable to that of flow cytometry; however, it is simple to operate and offers superior recognition capabilities for revealing multiple biomarkers. More importantly, this cell identification technology can be successfully applied in tumor tissues from breast cancer and lung cancer patients, demonstrating satisfactory practicability. Therefore, this work may provide new insights for the precise identification of cells, especially cancer cells, and is expected to offer technical support for clinical diagnosis and related biomedical research.<\/jats:p>","DOI":"10.1002\/adma.202504363","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T08:09:58Z","timestamp":1750147798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cell Surface\u2010Confined DNAzyme Coordination\u2010Facilitated Logical Engineering for Precise Cell Identification"],"prefix":"10.1002","volume":"37","author":[{"given":"Ya","family":"Cao","sequence":"first","affiliation":[{"name":"Center for Molecular Recognition and Biosensing Shanghai Engineering Research Center of Organ Repair Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education) School of Life Sciences Shanghai University  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