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However, their inherent limitations in activating cellular immunity pose critical challenges for vaccine development. In this study, chiral flower\u2010like aluminum oxyhydroxide (AlOOH) supraparticles (SPs) are synthesized via a one\u2010pot hydrothermal method using cysteine (Cys) enantiomers as chiral ligands, achieving a g\u2010factor of 0.004. L\u2010AlOOH SPs (L\u2010SPs) demonstrate significantly greater enhancement in dendritic cell (DC) maturation and antigen cross\u2010presentation efficiency compared to D\u2010AlOOH SPs (D\u2010SPs), indicating its potential as an adjuvant. Mechanistic studies reveal that L\u2010SPs enter DCs via Toll\u2010like receptor 2 (TLR2), thereby enhancing NOD\u2010like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation. In vivo experiments show that L\u2010SPs generate 21.59\u2010fold higher OVA\u2010specific antibody titers than commercial aluminum adjuvants. Further studies show that L\u2010SPs, after mixed with H9N2 virus proteins, enhance influenza virus antibody titers by 15.28\u2010fold, with sustained protection, confirming its translational potential. 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