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However, the limited delivery of checkpoint inhibitors to TDLNs and inadequate T cell priming persist as major challenges. In this study, an innovative dendritic cell (DC)\u2010based strategy is developed for the targeted delivery of ICB antibodies to TDLNs. The platform is fabricated by conjugating anti\u2010PD\u2010L1 antibody nanogels with DCs, which are further enhanced by pre\u2010treating DCs with tumor antigens. Subcutaneous administration enabled DCs to execute their intrinsic TDLN\u2010tropic migration, thus facilitating antibody delivery and release under reductive conditions. The antigen\u2010loaded DCs mobilized T cell immunity, while the anti\u2010PD\u2010L1 antibodies block PD\u2010L1 on dendritic cells and myeloid cells within TDLNs, thereby augmenting systemic antitumor immunity. This approach significantly suppresses breast cancer growth, leading to 83.3% of treated mice being tumor\u2010free. 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