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Nevertheless, current nanovaccines predominantly accumulate in subcapsular sinuses (SCS) or superficial cortical regions post\u2010lymphatic transport, failing to traverse anatomical barriers to reach the T cell\u2010enriched paracortex\u2014a critical delivery bottleneck that severely limits full activation of cellular immunity. Furthermore, the absence of tumor\u2010specific endogenous stimuli in LN microenvironments invalidates conventional environment\u2010responsive delivery strategies. Herein, \u201c\n                    <jats:bold>d<\/jats:bold>\n                    yn\n                    <jats:bold>a<\/jats:bold>\n                    mically\n                    <jats:bold>s<\/jats:bold>\n                    ize\u2010c\n                    <jats:bold>h<\/jats:bold>\n                    ange nanovaccine\u201d (DashVax), a time\u2010controlled self\u2010disassembling nanovaccine is presented that achieves dynamic size transition from 102 to 5 nm via physiologically regulated imine bond hydrolysis. This design capitalizes on the lymphatic drainage superiority of large particles and tissue\u2010penetrating capacity of small units, achieving a breakthrough 7.3\u2010fold enhancement in paracortical antigen delivery compared to non\u2010size\u2010change nanovaccines (NoncVax). DashVax demonstrates\u00a0robust antigen\u2010specific immune responses and tumor growth suppression in both B16\u2010OVA and MC38 tumor models. This exogenous stimulus\u2010free temporal delivery strategy not only redefines nanovaccine design principles but also elucidates fundamental correlations between intranodal delivery kinetics and immune activation efficacy.\n                  <\/jats:p>","DOI":"10.1002\/adma.202504909","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T07:14:31Z","timestamp":1752477271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Dynamic Size\u2010Change Nanovaccine for Enhancing Lymph Node Deep Penetration and Eliciting Robust Antitumor Immune Responses"],"prefix":"10.1002","volume":"37","author":[{"given":"Liping","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 China"},{"name":"School of Applied Chemistry and Engineering University of 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