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Here, we engineer bioinspired mechano\u2010intelligent Janus bandages (MIBs) with dynamically coordinated adhesion\u2013contraction for effective wound healing. The MIBs are fabricated through micromolding of poly(lactide\u2013co\u2013propylene glycol\u2013co\u2013lactide) dimethacrylates (PmLnD), featuring an interior surface with a gecko\u2010mimicking wedged structure. Upon application, the MIBs recapitulate the gecko locomotion principle to achieve precise control of contractile forces with dynamically coordinated adhesion\u2013contraction. The simply pre\u2010strained MIB can precisely program its intrinsic contractile force, while adhesion strength proportionally responds to the contractile force through enhanced van der Waals interactions and interfacial friction. This coordinated mechanism promotes healing in rat and porcine full\u2010thickness skin defect models by accelerating re\u2010epithelialization and enhancing angiogenesis. Mechanistically, the MIBs reduce focal adhesion kinase (FAK) expression, thereby regulating downstream pathways related to wound healing progression, including nuclear factor kappa B (NF\u2010\u03baB), Wnt, and transforming growth factor\u2010beta (TGF\u2010\u03b2) pathways, enabling scar\u2010attenuated wound healing. We envision that this Janus design, which integrates strain\u2010programmable contraction with reversible gecko\u2010inspired adhesion, offers a useful addition to current mechanobiological strategies for wound management and soft tissue repair.<\/jats:p>","DOI":"10.1002\/adma.202505122","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:01:32Z","timestamp":1778832092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Seta\u2010Inspired Mechano\u2010Intelligent Janus Bandage with Coordinated Adhesion\u2013Contraction for Minimizing Scarring"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0859-9877","authenticated-orcid":false,"given":"Di","family":"Suo","sequence":"first","affiliation":[{"name":"Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University  Hong Kong SAR P. R. 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