{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:55:09Z","timestamp":1792025709478,"version":"4.4.0"},"reference-count":73,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21CA267608"],"award-info":[{"award-number":["R21CA267608"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bladder cancer is a leading cause of cancer\u2010related mortality, yet current intravesical drug delivery methods often suffer from poor retention times in the bladder. Gecko feet\u2010like nanomaterials offer the potential to overcome this challenge, however, conventional methods to fabricate high surface area nanomaterials for drug delivery involve complex and expensive manufacturing processes. In this work, a simple fluid flow templating method is reported for manufacturing soft dendritic particles (SDPs) composed of poly(lactic\u2010<jats:italic>co<\/jats:italic>\u2010glycolic acid) (PLGA) with a chitosan coating for enhanced adhesion to epithelial tissues via van der Waals interactions. The biodegradable SDPs encapsulate chemotherapeutic agents and are administered using an alginate hydrogel, enabling precise deposition by extrusion for sustained drug release. The results demonstrate that SDPs adhere to mouse and human cancer cells for several days. The SDPs effectively encapsulate and release several clinically utilized chemotherapeutic drugs such as gemcitabine, docetaxel, and methotrexate, exhibiting superior cancer cell killing in vitro. In murine models, gemcitabine\u2010loaded SDPs instilled into tumor\u2010bearing bladders elicited stronger CD45+ immune cell responses than control groups while maintaining minimal toxicity. This work presents a simple, biomimetic drug delivery platform with prolonged retention and controlled drug release, offering a versatile approach for enhancing therapeutic delivery in epithelial cancer models.<\/jats:p>","DOI":"10.1002\/adma.202505231","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T03:57:14Z","timestamp":1751601434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Soft Extrudable Dendritic Particles with Nanostructured Tendrils for Local Adhesion and Drug Release to Bladder Cancers"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5708-2284","authenticated-orcid":false,"given":"Jin Gyun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Engineering University of Colorado Boulder  3415 Colorado Ave Boulder CO 80303 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Petraccione","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine University of Colorado Anschutz Medical Campus  12801 East 17th Avenue 8122 Aurora CO 80045 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Trese","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering University of Colorado Boulder  3415 Colorado Ave Boulder CO 80303 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-5884","authenticated-orcid":false,"given":"Alex C.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine University of Colorado Anschutz Medical Campus  12801 East 17th Avenue 8122 Aurora CO 80045 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor R.","family":"Ausec","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering University of Colorado Boulder  3415 Colorado Ave Boulder CO 80303 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Salzmann\u2010Sullivan","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine University of Colorado Anschutz Medical Campus  12801 East 17th Avenue 8122 Aurora CO 80045 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lih\u2010Jen","family":"Su","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine University of Colorado Anschutz Medical Campus  12801 East 17th Avenue 8122 Aurora CO 80045 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering University of Colorado Boulder  3415 Colorado Ave Boulder CO 80303 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3268-6214","authenticated-orcid":false,"given":"Sangchul","family":"Roh","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Chonnam National University  77, Yongbong\u2010ro, Buk\u2010gu Gwangju 61186 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7284-4005","authenticated-orcid":false,"given":"Andrew P.","family":"Goodwin","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering University of Colorado Boulder  3415 Colorado Ave Boulder CO 80303 USA"},{"name":"Materials Science and Engineering Program University of Colorado Boulder  1111 Engineering Drive, 521 UCB Boulder CO 80309 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6813-0027","authenticated-orcid":false,"given":"Frances Xiuyan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Colorado Anschutz Medical Campus  13001 E 17th Pl Aurora CO 80045 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-9040","authenticated-orcid":false,"given":"Thomas W.","family":"Flaig","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine University of Colorado Anschutz Medical Campus  12801 East 17th Avenue 8122 Aurora CO 80045 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4138-8462","authenticated-orcid":false,"suffix":"IV","given":"C. Wyatt","family":"Shields","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering University of Colorado Boulder  3415 Colorado Ave Boulder CO 80303 USA"},{"name":"Materials Science and Engineering Program University of Colorado Boulder  1111 Engineering Drive, 521 UCB Boulder CO 80309 USA"},{"name":"Biomedical Engineering Program University of Colorado Boulder  1111 Engineering Drive, 521 UCB Boulder CO 80309 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.06.010"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008880802285032"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.22"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-18-0063"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-024-00708-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2020.1810016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB01323E"},{"key":"e_1_2_8_9_1","first-page":"684","volume":"38","author":"Fujita N.","year":"2020","journal-title":"Urol. Oncol.: Semin. Orig. Invest."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2015.58"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.urolonc.2018.04.013","volume":"36","author":"Daneshmand S.","year":"2018","journal-title":"Urol. Oncol.: Semin. Orig. Invest."},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.urolonc.2018.10.019","volume":"37","author":"Elsawy A. A.","year":"2019","journal-title":"Urol. Oncol.: Semin. Orig. Invest."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500589"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202108049"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c12140"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207488"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.4c03005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307263"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401304"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192252799"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00380"},{"key":"e_1_2_8_22_1","first-page":"445","volume":"33","author":"Yu Z.","year":"2018","journal-title":"Int. J. Rob. Autom."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b01355"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/la8021485"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adem.202400149"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0508-z"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211438"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-024-01771-6"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202423494"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.5c00013"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/10837450.2020.1727921"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.3c03869"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c03723"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.3c00720"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201901633"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.16358"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp500439c"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10353"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsestengg.3c00109"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10722"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b17748"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.0c01613"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.0c00156"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja02242a004"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/la201898v"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.07.053"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002740"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.07.060"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567201817666200810110914"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2009.08.015"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201401076"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-2409"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305529"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-5428(08)60321-4"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012372551-6\/50071-7"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2012.01.002"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16040498"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-18915-9.00040-9"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.03.051"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.017"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202300409"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22810"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23098-9"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.09.052"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.03.024"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.09.003"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30512-8"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103160"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30437-2"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.5603\/ocp.98757"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-199803000-00001"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0176"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202505231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T07:00:20Z","timestamp":1759734020000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202505231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":73,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/adma.202505231"],"URL":"https:\/\/doi.org\/10.1002\/adma.202505231","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,4]]},"assertion":[{"value":"2025-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2505231"}}