{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:24:33Z","timestamp":1790047473002,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"39","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52472288"],"award-info":[{"award-number":["52472288"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20254"],"award-info":[{"award-number":["U20A20254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52072253"],"award-info":[{"award-number":["52072253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52203362"],"award-info":[{"award-number":["52203362"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The worsening hypoxia, acidity, immunosuppression, and low drug penetration created by arterial embolization significantly limit the therapeutic efficiency of transarterial chemoembolization (TACE) therapy. To overcome these problems, nanoscale magnesium hydride (MgH\n                    <jats:sub>2<\/jats:sub>\n                    ) gas bombs are synthesized and then are co\u2010dispersed with tirapazamine (TPZ) into lipiodol (Lip) to obtain an L\u2010MgH\n                    <jats:sub>2<\/jats:sub>\n                    &amp;TPZ suspension, in which the MgH\n                    <jats:sub>2<\/jats:sub>\n                    nanobombs efficiently modulate the worsened tumor microenvironment (TME), reversed immunosuppression, promoted drug penetration, and amplified TACE therapy. After being injected into mouse tumors, MgH\n                    <jats:sub>2<\/jats:sub>\n                    nanobombs react with water to effectively generate OH\n                    <jats:sup>\u2212<\/jats:sup>\n                    to neutralize the acidic TME and reverse immunosuppression; hydrogen (H\n                    <jats:sub>2<\/jats:sub>\n                    ) gas bubbles enhance TPZ penetration and achieve hydrogen\u2010based chemotherapy; and Mg\n                    <jats:sup>2+<\/jats:sup>\n                    synergistically regulates T\u2010cell function, resulting in significant inhibition for tumor growth. Moreover, the immunological effects of H\n                    <jats:sub>2<\/jats:sub>\n                    and Mg\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010induced antitumor immune responses further inhibit tumor growth and metastasis after combination with an immune checkpoint inhibitor. As demonstrated in the orthotopic rat liver cancer model, transarterial embolization of the L\u2010MgH\n                    <jats:sub>2<\/jats:sub>\n                    &amp;TPZ suspension offers greatly enhanced therapeutic outcomes, and all of tumors are eradicated after 3 weeks of treatment, further confirming that the introduction of the MgH\n                    <jats:sub>2<\/jats:sub>\n                    nanobombs significantly modulates the acidic\/immunosuppressive TME and promotes the penetration of TPZ to improve the efficacy of TACE therapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.202505770","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T09:27:06Z","timestamp":1752571626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Gas Nanobomb to Promote Drug Penetration and Amplify TACE Therapy for Orthotopic Liver Tumor"],"prefix":"10.1002","volume":"37","author":[{"given":"Minjiang","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research The Fifth Affiliated Hospital of Wenzhou Medical University Lishui 323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinwei","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research The Fifth Affiliated Hospital of Wenzhou Medical University Lishui 323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gong","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon Based Functional Materials &amp; Devices Soochow University Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon Based Functional Materials &amp; Devices Soochow University Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifan","family":"Pei","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon Based Functional Materials &amp; Devices Soochow University Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon Based Functional Materials &amp; Devices Soochow University Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaofeng","family":"Shu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research The Fifth Affiliated Hospital of Wenzhou Medical University Lishui 323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research The Fifth Affiliated Hospital of Wenzhou Medical University Lishui 323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research The Fifth Affiliated Hospital of Wenzhou Medical University Lishui 323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoju","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research The Fifth Affiliated Hospital of Wenzhou Medical University Lishui 323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon Based Functional Materials &amp; Devices Soochow University Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5324-9094","authenticated-orcid":false,"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon Based Functional Materials &amp; Devices Soochow University Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansong","family":"Ji","sequence":"additional","affiliation":[{"name":"Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research The Fifth Affiliated Hospital of Wenzhou Medical University Lishui 323000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2018.11.002"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.122"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0096"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26153"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.1831"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841850801958890"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01064.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020405"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040840"},{"key":"e_1_2_8_6_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08300-3"},{"key":"e_1_2_8_6_4","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0928-4"},{"key":"e_1_2_8_6_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2024.108634"},{"key":"e_1_2_8_6_6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.01.039"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.021"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00248-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01712.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.02.032"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000599"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15691"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2021.11.020"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c01300"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5933"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2020.100694"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-024-01221-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.12.039"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17485-x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488406775268192"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b05124"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.100851"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11060761"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21706"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06630-2"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwz199"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201604894"},{"key":"e_1_2_8_23_1","first-page":"399","volume":"24","author":"Lisa H B.","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401974"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202414929"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119855"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202505770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202505770","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202505770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:00:38Z","timestamp":1771394438000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202505770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":39,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/adma.202505770"],"URL":"https:\/\/doi.org\/10.1002\/adma.202505770","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"assertion":[{"value":"2025-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2505770"}}