{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:18:02Z","timestamp":1792124282906,"version":"4.4.0"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574405"],"award-info":[{"award-number":["82574405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373871"],"award-info":[{"award-number":["82373871"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019091","name":"Key Research and Development Program of Hunan Province of China","doi-asserted-by":"publisher","award":["2024JK2114"],"award-info":[{"award-number":["2024JK2114"]}],"id":[{"id":"10.13039\/501100019091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute kidney injury (AKI) has an alarmingly high annual incidence. Heterogeneous AKI shares a common pathological hallmark\u2014excessive reactive oxygen species (ROS), primarily generated from damaged proximal tubular epithelial cells (PTECs). Toxic ROS overload triggers mitochondrial dysfunction and excessive inflammation, initiating pathological crosstalk and vicious cycles that exacerbate AKI progression. However, many emerging preclinical therapeutic strategies or nanotechnologies face obstacles, including poor biocompatibility, inadequate targeting, and\/or complex assembly, which hinder drug delivery and clinical translation. To address these limitations, fully\u2010biocompatible tantalum\u2010based antioxidant nanoshields (fTANS) with megalin (PTECs receptor)\u2010mediated active targeting have been developed. fTANS combine the elegant delivery capability from albumin coating with the superior ROS\u2010scavenging efficiency from reduced tantalum. fTANS traverse the glomerular filtration barrier with ultra\u2010small particle size and actively internalize into PTECs via the affinity between megalin and albumin, sequentially targeting mitochondria due to their mitochondrial affinity. By modulating ROS signals, fTANS effectively preserve mitochondria, thereby limiting cytochrome\n                    <jats:italic>c<\/jats:italic>\n                    \u2010induced apoptosis and mitochondrial DNA\u2010triggered cGAS\/STING\u2010mediated sterile inflammation, ultimately leading to effective treatment in AKI models. Following treatment, fTANS are cleared via renal excretion without observable toxicity, exhibiting remarkable biocompatibility. Collectively, this work represents a compelling advancement in targeted antioxidant nanomedicine, offering a promising avenue for AKI treatment.\n                  <\/jats:p>","DOI":"10.1002\/adma.202506307","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:38:43Z","timestamp":1761118723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fully Biocompatible Tantalum\u2010Based Antioxidant Nanoshields for Proximal Tubule Epithelial Cells\u2010Targeted Mitochondrial Holistic Protection in Acute Kidney Injury"],"prefix":"10.1002","volume":"38","author":[{"given":"Yongqi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pharmacy Xiangya Hospital Central South University  Changsha 410008 China"},{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"},{"name":"Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaohui","family":"Chen","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"},{"name":"Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Ying","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"},{"name":"Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"},{"name":"Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"},{"name":"Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Miao","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"},{"name":"Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayun","family":"Nan","sequence":"additional","affiliation":[{"name":"Geriatric Medical Center People's Hospital of Ningxia Hui Autonomous Region  Yinchuan Ningxia 750002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Xiangya Hospital Central South University  Changsha 410008 China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University  Changsha 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-8963","authenticated-orcid":false,"given":"Kelong","family":"Ai","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"},{"name":"Hunan Provincial Key Laboratory of Cardiovascular Research Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410013 China"},{"name":"Key Laboratory of Aging\u2010related Bone and Joint Diseases Prevention and Treatment Ministry of Education Xiangya Hospital Central South University  Changsha 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00284-z"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-024-00820-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-022-06859-y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06454-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00519-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI188358"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1815208116"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.09.021"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.09.033"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0181-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308239"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00233-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02044-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-020-3067-3"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01086-x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-495887"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00902-0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2024.07.020"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01061422"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.4.9508063"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10060967"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01745-z"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01865-0"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.03.033"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000608"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01668-1"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.156"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33469-5"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2015.11.007"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00055.2006"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301585"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.983695"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-020-3250-1"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01089-z"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290049"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2013.139"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao6047"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201168119"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0215-7"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-022-00426-z"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.03.002"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01110-y"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-024-00819-z"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101534"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102151"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2013.181"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.10.023"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.07.102"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b05218"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c17579"},{"key":"e_1_2_10_51_1","volume":"12","author":"Weng Q.","year":"2021","journal-title":"Nat. Commun."},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202109221"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202409529"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202208571"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202506307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202506307","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202506307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T07:09:50Z","timestamp":1769670590000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202506307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/adma.202506307"],"URL":"https:\/\/doi.org\/10.1002\/adma.202506307","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,22]]},"assertion":[{"value":"2025-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e06307"}}