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Existing protein\u2010based physical barriers face the challenges of rapid degradation, lack of self\u2010adhesiveness, and the inability to promote PF healing. To overcome this, a novel enzyme\u2010resistant and highly bioactive hydrogel (CGO@Pg\u2010Cu(II)) is developed using glycidyl methacrylate recombinant collagen (enzyme\u2010cleavage\u2010free) and oxidized pullulan as backbone molecules, which is further loaded with a penicillin G\u2010Cu(II) infinite coordination polymer nanomedicine. This hydrogel can adapt to irregular PF wounds through injectable self\u2010leveling and achieve transient unilateral adhesion via light\u2010activated radical crosslinking with tissue\u2010inherent molecules. In vitro and in vivo studies demonstrate its ability to provide full\u2010cycle PF management by serving as a long\u2010lasting physical barrier while offering antimicrobial properties, rapid hemostasis, anti\u2010inflammatory effects, reversible fibrosis induction, and enhancing pancreatic tissue repair. The anti\u2010PF efficacy of the CGO@Pg\u2010Cu(II) hydrogel at day 7 is 100%, highlighting its strong potential for clinical postoperative PF prevention.<\/jats:p>","DOI":"10.1002\/adma.202506907","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T11:24:18Z","timestamp":1752233058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Light\u2010Activated Transient Unilateral Adhesive Recombinant Collagen\u2010Based Hydrogel for Reversible Fibrosis Induction and Full\u2010Cycle Management of Pancreatic Fistula"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1448-9823","authenticated-orcid":false,"given":"Shihong","family":"Shen","sequence":"first","affiliation":[{"name":"Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing Ministry of Education School of Chemical Engineering Northwest University  Xi'an 710127 China"},{"name":"Biotech. &amp; Biomed. 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