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In this study, a Trojan horse\u2010inspired biomimetic lipoprotein nanocarrier (A\u2010PA\u2010\u03b1CPP) is developed for noninvasive anti\u2010VEGF therapy via topical administration. Utilizing phosphatidic acid (PA), specifically 1,2\u2010dioleoyl\u2010sn\u2010glycero\u20103\u2010phosphate (DOPA), as the sole phospholipid, the nanocarrier enables electrostatic tethering of aflibercept, with a cell\u2010penetrating peptide (CPP)\u2010functionalized apoA1 mimetic peptide (\u03b1CPP) incorporated through self\u2010assembly. Molecular dynamics simulations and intermolecular interaction experiments confirm effective PA\u2013protein interactions and \u03b1CPP incorporation. The nanocarrier demonstrates high encapsulation efficiency, size uniformity, and long\u2010term stability. It enhances transcellular and paracellular transport by promoting cellular uptake, bypassing lysosomal degradation, and modulating tight junctions. 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