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Numerous studies focus on alleviating RD symptoms, but approaches to minimize the radiation dose to the skin are underexplored. Shielding skin\u2010damaging photons (10\u201320 keV) holds promise for skin dose reduction; however, this strategy is hindered by inadequate shielding efficiency of current RD biomaterials and overshielding by conventional high\u2010\n                    <jats:italic>Z<\/jats:italic>\n                    materials which attenuate therapeutic high\u2010energy photons. Here, inspired by the strong absorption of near\u2010threshold\u2010energy photons at the K\u2010edge, an energy\u2010selective shielding strategy by integrating selenium\u2010containing melanin nanoparticles with a carbomer hydrogel is proposed, developing an X\u2010ray filtering skin dressing (SeMNPs@Car). It exhibits up to 96% shielding for low\u2010energy X\u2010ray (10\u201320 keV) while maintaining over 98% transmission for high\u2010energy photons. In RD animal models, the SeMNPs@Car achieves 100% prevention of ulceration and the longest delay in the onset of RD (\u224820 days), outperforming clinical RD treatments. Furthermore, Monte\u2010Carlo\u2010based reconstruction of radiotherapy scenarios demonstrates its clinical applicability. This work incorporates photoelectric absorption properties into hydrogel design, providing valuable insights for RD management and the creation of soft\u2010material\u2010based X\u2010ray filters.\n                  <\/jats:p>","DOI":"10.1002\/adma.202508196","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T04:25:04Z","timestamp":1753763104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["K\u2010Edge\u2010Inspired Selenomelanin Hydrogel: An X\u2010Ray Filtering Biomaterial for Skin Protection in Radiotherapy"],"prefix":"10.1002","volume":"37","author":[{"given":"Hanjie","family":"Zhu","sequence":"first","affiliation":[{"name":"Key Laboratory of Radiopharmaceuticals of the Ministry of Education College of Chemistry Beijing Normal University Beijing 100875 China"},{"name":"School of Physics and Astronomy Beijing Normal University Beijing 100875 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