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How HSV\u20101 reaches the brain from the initial infection site remains inconclusive. Here, an innovative approach combining carbon quantum dots (CQDs) with dissolving microneedles (dMN) for real\u2010time tracking of HSV\u20101 from skin to brain is presented. Upon application, CQDs\u2010HSV\u20101 is released from the dMN through the swelling of interstitial fluid (ISF) in skin and subsequently monitored by living imaging. Remarkably, it is observed that HSV\u20101 preferentially infects peripheral skin nerves, almost all viruses directly enter to brain via the spinal cord within 10\u201330\u00a0min, while few viruses enter the brain through the bloodstream via tail vein injection at the same time. Spinal cord injury (SCI) significantly delays the HSV\u20101 transport from skin to brain but has no effect on the virus's travel from blood to brain. In a microfluid system, HSV\u20101 shows preferential neurite infection, then transports to the cell body of differentiated SH\u2010SY5Y cells, highlighting the viral traffic process in neurons. The integration of CQDs\u2010virus labelling technology and dMN delivery model presents a promising tool for investigating the in vivo transport routes of neurotropic viruses with initial skin infections.<\/jats:p>","DOI":"10.1002\/adma.202508464","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T01:48:21Z","timestamp":1751852901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Carbon Quantum Dots Assisted Virus Tracking: From Skin to Brain"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9488-8404","authenticated-orcid":false,"given":"Yaxiu","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cien","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changshun","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiran","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LeiYing","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianya","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Liang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences City University of Hong Kong  Hong Kong SAR 999077 China"},{"name":"Tung Biomedical Science Center City University of Hong Kong  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,6]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2020.03.003"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad419"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02376-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2491"},{"key":"e_1_2_9_5_1","volume":"97","author":"Zubkovic\u0301 A.","year":"2023","journal-title":"J. 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