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To address this issue, optimizing the magnetic diameter of MNPs is focused on, a pivotal parameter influenced by both physical size and magnetic disorder, yet underexplored in the development of MPI tracers. By employing a precise temperature\u2010controlled synthesis strategy, this study successfully modulates these parameters synergistically to create high\u2010performance Fe\n                    <jats:sup>310<\/jats:sup>\n                    P with an optimal magnetic diameter, exhibiting an eight\u2010fold increase in the MPI signal in vitro compared to the commercial tracer VivoTrax. Further surface functionalization with engineered macrophage membranes expressing a prostate\u2010specific membrane antigen (PSMA)\u2010targeting antibody fragment (gy\u20101) yields tumor\u2010targeted Fe\n                    <jats:sup>310<\/jats:sup>\n                    4PM\n                    <jats:sup>gy\u20101<\/jats:sup>\n                    , which enables the detection of as few as 800 tumor cells with a single scan, without the need for repeated acquisitions. Compared to VivoTrax, Fe\n                    <jats:sup>310<\/jats:sup>\n                    4PM\n                    <jats:sup>gy\u20101<\/jats:sup>\n                    achieves a 330\u2010fold enhancement in the MPI signal in vivo, which enables the sensitive detection of prostate tumors and bone metastasis with 0.5\u00a0mm in diameter. This study provides valuable insights into the development of advanced MPI tracers, paving the way for broader biomedical applications of MPI.\n                  <\/jats:p>","DOI":"10.1002\/adma.202508495","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T13:14:43Z","timestamp":1753535683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Unleashing the Power of Magnetic Particle Imaging: Tailored Magnetic Nanoparticles for Ultrasensitive Detection of Bone Metastases in Prostate Cancer"],"prefix":"10.1002","volume":"37","author":[{"given":"Haohao","family":"Yan","sequence":"first","affiliation":[{"name":"Lab of Molecular Imaging and Translational Medicine (MITM) Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University  Xi'an Shaanxi 710126 P. R. 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