{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:51:38Z","timestamp":1789469498895,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"50","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473009"],"award-info":[{"award-number":["82473009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["MOE\u2010T2EP50223\u20100004"],"award-info":[{"award-number":["MOE\u2010T2EP50223\u20100004"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Orchestration of enzyme cascades in synthetic systems remains a major challenge for catalytic control in complex biological environments. Here, a zinc\u2010coordinated tri\u2010enzyme nanogel system (Zn@nGSC) is reported that mimics natural enzymatic assemblies by confining individual glucose oxidase (GOX), superoxide dismutase (SOD), and catalase (CAT) within an imidazole\u2010functionalized polymeric nanogel matrix. The nanogel is fabricated via mild in situ polymerization combined with Zn\n                    <jats:sup>2<\/jats:sup>\n                    \u207a\u2010imidazole coordination, yielding structurally stable multi\u2010enzyme assemblies. The engineered assemblies demonstrate simultaneous preservation of enzymatic activity and enhanced cascade efficiency under thermal and proteolytic stress. Cascade reactions proceed as follows: i) glucose is depleted by GOX, ii) superoxide radicals are scavenged by SOD to alleviate oxidative stress, and iii) residual H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    is converted into oxygen by CAT in order to mitigate hypoxia. Functionally, Zn@nGSC restores redox balance and metabolic homeostasis, demonstrated in a murine model of post\u2010pancreatectomy wound healing, with emphasis on treating hyperglycemia and improving regeneration. Another pronounced advantage of Zn@nGSC treatment is its antibacterial effect, which enhances angiogenesis, collagen deposition, and immune modulation. Overall, this modular nanoplatform provides a blueprint for designing robust, bioresponsive cascade systems with therapeutic potential in metabolically compromised microenvironments.\n                  <\/jats:p>","DOI":"10.1002\/adma.202508538","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T06:43:53Z","timestamp":1754030633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Zinc\u2010Coordinated Trienzyme Nanogel Cascade Therapy for Accelerated Post\u2010Pancreatectomy Cutaneous Wound Healing"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-5045","authenticated-orcid":false,"given":"Yedong","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering National University of Singapore  9 Engineering Drive 1 Singapore 117576 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengke","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery Fuzhou University Affiliated Provincial Hospital Fujian Provincial Hospital  Fuzhou 350001 China"},{"name":"Shengli Clinical Medical College of Fujian Medical University  Fuzhou 350001 China"},{"name":"Fuzhou University  Fuzhou 350001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery Fuzhou University Affiliated Provincial Hospital Fujian Provincial Hospital  Fuzhou 350001 China"},{"name":"Shengli Clinical Medical College of Fujian Medical University  Fuzhou 350001 China"},{"name":"Fuzhou University  Fuzhou 350001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering National University of Singapore  9 Engineering Drive 1 Singapore 117576 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering National University of Singapore  9 Engineering Drive 1 Singapore 117576 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Kong","sequence":"additional","affiliation":[{"name":"Institute of Materials Research and Engineering (IMRE) Agency for Science Technology and Research (A\u2217STAR) Innovis  2 Fusionopolis Way Singapore 138634 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2574-5776","authenticated-orcid":false,"given":"Xiaotong","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Sustainability for Chemicals Energy and Environment (ISCE2) Agency for Science Technology and Research (A*STAR)  1 Pesek Road, Jurong Island Singapore 627833 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zibiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering National University of Singapore  9 Engineering Drive 1 Singapore 117576 Singapore"},{"name":"Institute of Materials Research and Engineering (IMRE) Agency for Science Technology and Research (A\u2217STAR) Innovis  2 Fusionopolis Way Singapore 138634 Singapore"},{"name":"Institute of Sustainability for Chemicals Energy and Environment (ISCE2) Agency for Science Technology and Research (A*STAR)  1 Pesek Road, Jurong Island Singapore 627833 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery Fuzhou University Affiliated Provincial Hospital Fujian Provincial Hospital  Fuzhou 350001 China"},{"name":"Shengli Clinical Medical College of Fujian Medical University  Fuzhou 350001 China"},{"name":"Fuzhou University  Fuzhou 350001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8200-8337","authenticated-orcid":false,"given":"Chaobin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering National University of Singapore  9 Engineering Drive 1 Singapore 117576 Singapore"},{"name":"Institute of Materials Research and Engineering (IMRE) Agency for Science Technology and Research (A\u2217STAR) Innovis  2 Fusionopolis Way Singapore 138634 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.7b01766"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-022-00931-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b04921"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2459"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.54"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2023.102930"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-27983-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2023.102889"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-0737-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202403116"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.724"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202405644"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2012.264"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NR04171E"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202408787"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.5834"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004757"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000998"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-025-06376-9"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30106-6"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2012.12.017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00261-2"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc5569"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01035-z"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67700-8"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2025.14880"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj0153"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh1415"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.20230047"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.04.033"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.024"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.3c00198"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202110048"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b04457"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202200871"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2022.107951"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.64244"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100716"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2549"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.10.006"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1683"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.75"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3180"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00965-1"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2024.100621"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202502830"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.01.010"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwae044"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202419158"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303548"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adp2974"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02128-2"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50450-6"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202508538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T14:15:52Z","timestamp":1765980952000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202508538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":53,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/adma.202508538"],"URL":"https:\/\/doi.org\/10.1002\/adma.202508538","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]},"assertion":[{"value":"2025-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e08538"}}