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Traditional treatment modalities often prove inadequate, constrained by limited bioavailability, and their extended use may result in serious complications, including secondary infections, glaucoma, and cataracts. However, recent progress in nanomaterials has led to promising therapeutic approaches for CoNV therapy. These nanomaterials, serving as carriers for anti\u2010vascular endothelial growth factor (anti\u2010VEGF) drugs or corticosteroids, exhibit remarkable capabilities in efficient penetration, adhesion, targeted drug delivery, and controlled release. Furthermore, they demonstrate independent inhibitory effects on neovascularization, thereby paving the way for a comprehensive treatment strategy that encompasses both the microenvironment and molecular pathways. This review offers a systematic classification of innovative drug delivery systems specifically tailored for the cornea. 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