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To address this issue, a strategy is developed to tailor the in vivo behavior of \u03c0\u2010conjugate fluorophores by breaking\n                    <jats:italic>\u03c0<\/jats:italic>\n                    \u2013\n                    <jats:italic>\u03c0<\/jats:italic>\n                    stacking in polymer brush\u2010engineered unimolecular micelles. This approach marks a significant shift from traditional methods of tuning micelles, which rely on varying the hydrophilic\u2010to\u2010hydrophobic ratios and are often ineffective for \u03c0\u2010conjugated systems due to the dominance of\n                    <jats:italic>\u03c0<\/jats:italic>\n                    \u2013\n                    <jats:italic>\u03c0<\/jats:italic>\n                    interactions. By disrupting\n                    <jats:italic>\u03c0<\/jats:italic>\n                    \u2013\n                    <jats:italic>\u03c0<\/jats:italic>\n                    interactions in the unimolecular micelles, pharmacokinetics and photophysical properties can be precisely controlled by systematically varying the molecular weight and composition of the polymer brushes. Accordingly, the blood circulation half\u2010life can be adjusted across a 60\u2010fold range, and fluorescence emissions are improved by 47\u2010fold, facilitating adaptive fluorophore applications from kidney dysfunction detection to tumor imaging. Additionally, the engineered unimolecular micelles exhibit reduced nonspecific uptake and improved tumor targeting efficiency, resulting in a 5\u2010fold higher tumor\u2010to\u2010liver ratio than conventional\n                    <jats:italic>\u03c0<\/jats:italic>\n                    \u2013\n                    <jats:italic>\u03c0<\/jats:italic>\n                    stacked nano\u2010aggregates. These findings offer a solid solution to the pharmacokinetic optimization issues and provide a new design principle for \u03c0\u2010conjugated phototheranostic materials.\n                  <\/jats:p>","DOI":"10.1002\/adma.202509266","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T09:46:20Z","timestamp":1755942380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Universal NIR\u2010II\u2010Emitting Unimolecular Micelles with Tailorable Pharmacokinetic and Optical Properties for Adaptive Imaging"],"prefix":"10.1002","volume":"37","author":[{"given":"Shengxin","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering Southern University of Science and Technology  1088 Xueyuan Blvd., Nanshan District Shenzhen Guangdong 518055 P. R. 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