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Due to factors such as the blood\u2010labyrinth barrier and the unique structure of the cochlea, there is still a lack of an effective and sustainable targeted drug delivery system. The development of inner ear drug delivery systems capable of sustaining therapeutic concentrations with site\u2010specific localization remains a critical challenge in otopharmacology. In this paper, we engineered a magnetically navigable platform utilizing mesoporous silica nanoparticles (MMSNs) for precision\u2010targeted cochlear drug administration. This system features a magnetic\u2010responsive core and a permeable porous shell, combining the advantages of both nanomaterial carriers and\n                    <jats:italic>Lycium barbarum<\/jats:italic>\n                    glycopeptide (LbGP). The resultant MMSNs\u2010LbGP nanocomposite exhibited good biocompatibility, antioxidant, and anti\u2010inflammatory activities. In a guinea pig model of noise\u2010induced hearing loss, MMSNs\u2010LbGP treatment not only effectively restored auditory function and preserved cochlear hair cell structure but also significantly attenuated cochlear neuroinflammation and oxidative damage. This advancement establishes a novel framework for translational implementation of nanoparticle\u2010mediated inner ear therapy, offering therapeutic solutions to rehabilitate or functionally augment auditory pathways in patients with sensorineural deficits.\n                  <\/jats:p>","DOI":"10.1002\/adma.202509502","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:06:48Z","timestamp":1768381608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Magnetic Mesoporous Nanoparticles Loaded with\n                    <i>Lycium barbarum<\/i>\n                    Glycopeptide for Targeted Therapy of Noise\u2010Triggered Auditory Dysfunction"],"prefix":"10.1002","volume":"38","author":[{"given":"Menghui","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Zhongda Hospital State Key Laboratory of Digital Medical Engineering 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