{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:47:59Z","timestamp":1793195279094,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82303778 No. 32000996"],"award-info":[{"award-number":["No. 82303778 No. 32000996"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cancer immunotherapy leveraging vaccine\u2010based approaches has emerged as a promising strategy for long\u2010term tumor regression and metastasis prevention. However, the design of effective vaccines remains challenging due to the need for efficient lymph node (LN) targeting, dendritic cell (DC) uptake, and robust cellular immunity activation. Here, a proton\u2010driven, multifunctional nanovaccine (PP@Pt\u2010OVA) is presented that combines intelligent morphology regulation and nanozyme catalysis to address these challenges. The nanovaccine, comprising PVP@Pt nanozymes and OVA\n                    <jats:sub>257\u2013264<\/jats:sub>\n                    peptides encapsulated in PEG\u2010b\u2010PAE micelles, undergoes proton\u2010driven morphology transformation in acidic LN microenvironments, enhancing particle size and reducing PEGylation for optimized LN retention and DC uptake. Once internalized, PVP@Pt nanozyme catalyzes reactive oxygen species (ROS) production, facilitating endosomal escape, antigen cross\u2010presentation, and DC maturation. PP@Pt\u2010OVA demonstrated efficient LN targeting, robust CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell activation, and significant tumor inhibition in both prophylactic and therapeutic melanoma models, with excellent biocompatibility and minimal systemic toxicity. These findings highlight the potential of PP@Pt\u2010OVA as a versatile nanovaccine platform, offering a rational design framework for overcoming the limitations of subunit vaccines and advancing cancer immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.202509994","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:30:03Z","timestamp":1761388203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Proton\u2010Driven Deformability Enables Nanozyme\u2010Integrated Vaccine for Enhanced Tumor Immunotherapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Jingyi","family":"An","sequence":"first","affiliation":[{"name":"Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University  Zhengzhou 450001 China"},{"name":"Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science Zhengzhou University  Zhengzhou Henan 451163 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Yang","sequence":"additional","affiliation":[{"name":"Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Feng","sequence":"additional","affiliation":[{"name":"Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghui","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University  Zhengzhou 450001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyun","family":"Yan","sequence":"additional","affiliation":[{"name":"Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University  Zhengzhou 450001 China"},{"name":"Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science Zhengzhou University  Zhengzhou Henan 451163 China"},{"name":"CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics, Chinese Academy of Sciences  Beijing 100101 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5389-3293","authenticated-orcid":false,"given":"Bing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University  Zhengzhou 450001 China"},{"name":"Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science Zhengzhou University  Zhengzhou Henan 451163 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"47","volume":"4","author":"Han B.","year":"2022","journal-title":"J. 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