{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:08:36Z","timestamp":1791914916323,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M732429"],"award-info":[{"award-number":["2023M732429"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bone defect therapy frequently encounters bacterial infections and chronic inflammation, which impair bone regeneration and threaten implant stability. Iron oxide nanoparticles have attracted attention due to cost\u2010effectiveness, biocompatibility, and metabolic safety. However, iron oxide nanoparticles still struggle to balance low\u2010temperature efficient antibacterial activity, effective immunomodulation, and bone regeneration. Therefore, inspired by diatoms, a multifunctional bone repair scaffold based on chitosan\u2010hydroxyapatite (CH) is developed by integrating the multifunctional properties of copper\u2010doped iron goethite (Fe(Cu)OOH) nanoparticles and a mesoporous SiO\n                    <jats:sub>2<\/jats:sub>\n                    protective layer (CH\/FeCu@SiO\n                    <jats:sub>2<\/jats:sub>\n                    ). The \u201ccytoskeleton\u201d CH scaffold stabilizes the nanoparticles and supports tissue growth. The \u201cchloroplast\u201d Fe(Cu)OOH and the \u201c frustule\u201d SiO\n                    <jats:sub>2<\/jats:sub>\n                    layer synergistically capture near\u2010infrared (NIR) light to generate localized mild hyperthermia (\u224842\u00a0\u00b0C), with the release of Cu\n                    <jats:sup>2+<\/jats:sup>\n                    to achieve antibacterial effects (&gt;99%). In addition, Fe(Cu)OOH exhibits enzyme\u2010like antioxidant activity, scavenging reactive oxygen species (ROS) (69.20%) and thereby promoting M2 macrophage polarization (1.64\u2010fold), which protects stem cells and creates osteogenic immune microenvironment. Moreover, the mild hyperthermia and ion release upregulate the TGF\u2010\u03b2 signaling pathway and inhibit osteoclast differentiation, promoting vascularized bone regeneration and defect repair (1.3\u2010fold). Overall, this biomimetic scaffold, enabling synergistic antibacterial, immunomodulatory, and osteogenic activities, offers a promising therapeutic strategy for infectious bone defects treatment.\n                  <\/jats:p>","DOI":"10.1002\/adma.202509997","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T12:06:09Z","timestamp":1757505969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Diatom\u2010Inspired Scaffold for Infected Bone Defect Therapy: Achieving Stable Photothermal Properties and Coordinated Antibacterial\u2010Osteogenic Functions"],"prefix":"10.1002","volume":"38","author":[{"given":"Xinyi","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials (Sichuan University) Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxuan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan 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University) Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials (Sichuan University) Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Advanced Polymer Materials (Sichuan University) Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University  Chengdu 610041 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