{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:45:47Z","timestamp":1792421147773,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"45","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 52402340"],"award-info":[{"award-number":["NSFC 52402340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20347"],"award-info":[{"award-number":["U22A20347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dendritic mesoporous organosilica (DMOS) nanoparticles are widely used to transport therapeutic agents to cancer sites and rapidly release them owing to their rapid biodegradability in the tumor microenvironment (TME). However, the role of these DMOS nanoparticles as nanocarriers is limited, and their applications remain relatively simple. In this study, Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010doped dendritic mesoporous organosilica (Fe\u2010DMOS) nanoparticles are designed as a new type of ferroptosis inducer and are combined with sodium hyaluronate\u2010modified calcium peroxide to form TME\u2010responsive nanocomposites. The nanocomposites can effectively generate a large number of hydroxyl radicals through the Fenton reaction between the released Fe\n                    <jats:sup>3+<\/jats:sup>\n                    and self\u2010compensated hydrogen peroxide, and mitochondrial injury caused by Ca\n                    <jats:sup>2+<\/jats:sup>\n                    overload further promotes this process. Both Fe\n                    <jats:sup>3+<\/jats:sup>\n                    and disulfide bonds can induce glutathione depletion, thus downregulating the expression of glutathione peroxidase 4 and triggering lethal levels of lipid peroxidation products, further facilitating ferroptosis in tumor cells. Additionally, the ferroptosis\u2010mediated process of immunogenic cell death promotes a long\u2010term antitumor immune response to prevent metastasis of tumor cells with the assistance of an immune checkpoint inhibitor (anti\u2010PD\u20101). Fe\u2010DMOS nanoparticles are synthesized with ferroptosis\u2010inducing capabilities and established TME\u2010responsive nanocomposites combined with an immune checkpoint inhibitor to effectively improve tumor immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.202510010","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T08:23:37Z","timestamp":1756196617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Tumor Microenvironment\u2010Activated Fe\n                    <sup>3+<\/sup>\n                    \u2010Doped Dendritic Mesoporous Organosilica Nanocomposites as Ferroptosis Inducers for Enhanced Immunotherapy"],"prefix":"10.1002","volume":"37","author":[{"given":"Lili","family":"Feng","sequence":"first","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Sang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Cancer Institute Affiliated Tumor Hospital of Nantong University  Nantong 226631 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghao","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. 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