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Effectively harnessing its beneficial effects while mitigating its harmful impacts is pivotal for advancing H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010based therapies. Here, an innovative H\n                    <jats:sub>2<\/jats:sub>\n                    S supply system is introduced that enables H\n                    <jats:sub>2<\/jats:sub>\n                    S to primarily exhibit its therapeutic effects. Unlike conventional synthetic H\n                    <jats:sub>2<\/jats:sub>\n                    S donor\u2010based strategies, a biomimetic H\n                    <jats:sub>2<\/jats:sub>\n                    S supply system (termed CP) is presented that mimics endogenous enzymatic H\n                    <jats:sub>2<\/jats:sub>\n                    S production. The CP sustainably produces H\n                    <jats:sub>2<\/jats:sub>\n                    S at a constant rate throughout the dosing period, ensuring therapeutic benefits while avoiding toxicity. Furthermore, by functionalizing CP with hyaluronic acid, the resulting system (CPH) not only achieves targeted delivery to inflammatory bowel disease (IBD) tissues but also provides controllable H\n                    <jats:sub>2<\/jats:sub>\n                    S production within the diseased microenvironment. Consequently, CPH significantly mitigates immune inflammation, promotes intestinal epithelial barrier repair, and modulates gut microbiota by sustainably and constantly supplying the multifunctional H\n                    <jats:sub>2<\/jats:sub>\n                    S. This study revolutionizes the H\n                    <jats:sub>2<\/jats:sub>\n                    S supply strategies and provides new insights into gas\u2010based therapies.\n                  <\/jats:p>","DOI":"10.1002\/adma.202510602","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T06:48:26Z","timestamp":1759128506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Promising Biomimetic Hydrogen Sulfide System for Advancing Inflammatory Disease Treatment"],"prefix":"10.1002","volume":"38","author":[{"given":"Chaoqiang","family":"Qiao","sequence":"first","affiliation":[{"name":"Engineering Research Center of Molecular &amp; Neuroimaging Ministry of Education School of Life Science and Technology Xidian University  Xi'an 710126 P. R. China"},{"name":"Guangzhou Institute of Technology Xidian University  Guangzhou 510555 P. R. 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