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Epidermal growth factor receptor (EGFR) plays an important role in the development of the nervous system, but its potential in nerve regeneration and repair has remained underappreciated. Herein, a chiral nanoagonist,\n                    <jats:italic>D<\/jats:italic>\n                    \u2010Histidine ZnO nanorods (NRs), is reported to effectively activate EGFR and initiate multiple downstream cascade signaling pathways, promoting nerve cell proliferation, differentiation, and migration in three different types of neural cells.\n                    <jats:italic>D<\/jats:italic>\n                    \u2010Histidine ZnO NRs not only achieve more than 85% differentiation rate (with neurite length larger than 50 \u00b5m), but also induce the transdifferentiating of Schwann cells into a stem\u2010like phenotype. A biodegradable band\u2010aid\u2010like bandage incorporating\n                    <jats:italic>D<\/jats:italic>\n                    \u2010Histidine ZnO NRs is developed and applied in nerve injury repair in both sciatic nerve and spinal cord injury models. The neurorestoration and functional recovery are significantly improved after 4\u2010week therapy. This study reveals that chirality\u2010dependent regulation of nerve cell behavior by chiral nanoagonist targeting EGFR is a pioneering and promising strategy in nerve regeneration therapies.\n                  <\/jats:p>","DOI":"10.1002\/adma.202510689","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:44:52Z","timestamp":1763369092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chiral Nanoagonist Targeting EGFR for Nerve Injury Repair"],"prefix":"10.1002","volume":"38","author":[{"given":"Xiaoyu","family":"Zhao","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Biosensing and Molecular Recognition Research Center for Analytical Science Frontiers Science Center for New Organic Matter College of Chemistry Nankai University  Tianjin 300071 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