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Herein, a one\u2010step cell engineering strategy is reported to enhance T cell therapy for solid tumors using an immuno\u2010packed T\u2010cell\u2010fusogenic liposome (IMPACTFUL). Through membrane fusion, IMPACTFUL simultaneously decorates therapeutic T cells with\n                    <jats:sup>D<\/jats:sup>\n                    PPA peptides on their surface and delivers interleukin\u201012 mRNA\u2010loaded magnetic nanoparticle cores (MNP\/IL\u201012) into the cytoplasm. MNP\/IL\u201012 internalization grants T cells with effective tumor targeting under external magnet and TME reversion through IL\u201012 expression.\n                    <jats:sup>D<\/jats:sup>\n                    PPA peptide presentation enables T cells to overcome tumor cells\u2019 immune tolerance through PD\u2010L1 checkpoint blockade. In a murine solid tumor model, IMPACTFUL\u2010engineered T cells infiltrate tumors more effectively, resist exhaustion, and induce a more pro\u2010inflammatory TME, leading to significantly suppressed tumor growth compared to unmodified T cells. Together, IMPACTFUL can empower adoptive T cell therapy by endowing T cells with multiple complementary functions in a single step. This approach offers a versatile platform to improve the therapeutic outcomes of T cell therapies against solid tumors and can accelerate their translation to clinical settings.\n                  <\/jats:p>","DOI":"10.1002\/adma.202510842","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T12:45:28Z","timestamp":1759841128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immuno\u2010Packed T\u2010Cell\u2010Fusogenic Liposome Empowers Adoptive T Cell Therapy for Solid Tumor Treatment"],"prefix":"10.1002","volume":"38","author":[{"given":"Chunxiong","family":"Zheng","sequence":"first","affiliation":[{"name":"Laboratory of Biomaterials and Translational Medicine Center for Nanomedicine, The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510630 China"},{"name":"School of Chemistry South China Normal University  Guangzhou 510006 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Center for Nanomedicine, The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Translational Medicine Center for Nanomedicine, The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enguo","family":"Ju","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Translational Medicine Center for Nanomedicine, The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510630 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeh\u2010Hsing","family":"Lao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University at Buffalo The State University of New York  Buffalo NY 14214 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