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This study addresses these barriers by reconstructing the nerve regeneration microenvironment, enhancing cell migration, and accelerating axonal growth. An integrated regenerative microenvironment combining chemical signals, micro\/nano structures, and electrical stimulation is developed. Specifically, nitric oxide (NO), a versatile signaling molecule, is dynamically released using sustained and responsive\u2010release strategies to regulate oxidative stress and inflammation effectively. Furthermore, a gelatin\u2013lipoic acid\u2013seleno\u2010lipoic acid (Gel\u2010LA\u2010SA) microgel\u2010based hydrogel is designed, forming interconnected macroporous scaffolds that significantly enhance cell infiltration and growth compared to traditional hydrogels. Additionally, a non\u2010invasive electroactive conduit is constructed to provide external electrical stimulation, promoting nerve cell migration and nerve growth factor secretion. 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