{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:33:25Z","timestamp":1792607605403,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2603900"],"award-info":[{"award-number":["2022YFC2603900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52273294"],"award-info":[{"award-number":["52273294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Multidrug\u2010resistant (MDR)\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ), classified as a high\u2010priority tier II pathogen, poses a glowing threat to global health. Single\u2010mode antibacterial approaches often fall short of achieving optimal effects, necessitating the development of combination therapies. To address these challenges, pH\u2010responsive antibacterial nanovesicles, termed DAClLy, are developed by integrating targeting ligand and multiple antimicrobial agents with complementary modes of action to target MDR bacteria with enhanced efficacy while minimizing adverse effects. DAClLy are engineered through the complexation of sulfonium\u2010ion\u2010bearing antibacterial polypeptoids, and primary amine\u2010containing polypeptoids modified with 2,3\u2010dimethyl maleic anhydride, encapsulating lysostaphin, a bacteriolytic enzyme. Upon reaching the acidic microenvironment of bacterial infections, the DAClLy vesicles disassemble, releasing their antimicrobial components. The released lysostaphin degrades bacterial cell walls, while the polypeptoids synergistically disrupt bacterial membranes, resulting in a multi\u2010action bactericidal effect. This synergistic mechanism demonstrates remarkable efficacy against MDR\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , including its resilient biofilm formations. In vivo studies have shown that the DAClLy vesicles exhibit potent antibacterial activity against MDR\n                    <jats:italic>S. aureus<\/jats:italic>\n                    \u2010induced skin and lung infections. The nanovesicles effectively penetrate the lung mucus barrier, addressing both surface\u2010level and deep\u2010tissue infections. By integrating multiple strategies, DAClLy offers a promising therapeutic strategy to combat MDR pathogens across diverse tissue contexts.\n                  <\/jats:p>","DOI":"10.1002\/adma.202511037","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T09:58:26Z","timestamp":1758016706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Targeted Cascade Therapy with Multifunctional Nanovesicles Engineered from Synergistic Antibacterial Agents for Precision Treatment of Multidrug\u2010Resistant Infections and Biofilms"],"prefix":"10.1002","volume":"38","author":[{"given":"Yiyu","family":"Gong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun Jilin 130012 P. R. 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