{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:19:25Z","timestamp":1783117165807,"version":"3.54.6"},"reference-count":62,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A20258"],"award-info":[{"award-number":["U25A20258"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271126"],"award-info":[{"award-number":["82271126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Thyroid\u2010associated ophthalmopathy (TAO), a vision\u2010threatening and disfiguring autoimmune orbital disorder, remains a therapeutic challenge due to the lack of therapies with orbital specificity, sustained efficacy, and minimal side effects. Herein, we present G4F7\u2010CRISPR, a fluoropolymer\u2010based CRISPR\u2010Cas9 delivery platform engineered for localized and efficient disruption of thyroid\u2010stimulating hormone receptor (\n                    <jats:italic>TSHR<\/jats:italic>\n                    ) and insulin\u2010like growth factor 1 receptor (\n                    <jats:italic>IGF1R<\/jats:italic>\n                    ), two key mediators of TAO pathogenesis. G4F7\u2010CRISPR achieved high insertion\/deletion frequencies in primary orbital fibroblasts (\n                    <jats:italic>Tshr<\/jats:italic>\n                    : 37.2%;\n                    <jats:italic>Igf1r<\/jats:italic>\n                    : 42.8%) and mature adipocytes (\n                    <jats:italic>Tshr<\/jats:italic>\n                    : 22.4%;\n                    <jats:italic>Igf1r<\/jats:italic>\n                    : 24.3%), and maintained robust editing efficiency in orbital adipose tissue of TAO mouse models (\n                    <jats:italic>Tshr<\/jats:italic>\n                    : 30.7%;\n                    <jats:italic>Igf1r<\/jats:italic>\n                    : 32.4%). In both TAO mouse models and 3D human orbital organoids, dual\u2010gene editing of\n                    <jats:italic>Tshr<\/jats:italic>\n                    and\n                    <jats:italic>Igf1r<\/jats:italic>\n                    via G4F7\u2010CRISPR significantly suppressed orbital adipogenesis, inflammation, and fibrosis, demonstrating superior therapeutic efficacy over either single\u2010gene approaches. Comprehensive off\u2010target analyses in both TAO mouse models and orbital organoids revealed minimal off\u2010target activity. Furthermore, G4F7\u2010CRISPR exhibited excellent short\u2010 and long\u2010term ocular and systemic safety in TAO mouse models. Notably, it outperformed teprotumumab\u2014the FDA\u2010approved therapy for TAO\u2014in both therapeutic efficacy and safety, highlighting its potential clinical advantages. Collectively, these findings highlight the translational promise of G4F7\u2010CRISPR as a safe, precise, and clinically viable gene therapy for TAO.\n                  <\/jats:p>","DOI":"10.1002\/adma.202511078","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:37:22Z","timestamp":1767598642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fluoropolymer\u2010Mediated Delivery of a Dual TSHR\/IGF1R\u2010Targeting CRISPR\u2010Cas9 System for Localized Therapy in Thyroid\u2010Associated Ophthalmopathy"],"prefix":"10.1002","volume":"38","author":[{"given":"Mingsu","family":"Shi","sequence":"first","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panting","family":"Yu","sequence":"additional","affiliation":[{"name":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences East China Normal University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runyi","family":"Shao","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Sun","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Lv","sequence":"additional","affiliation":[{"name":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences East China Normal University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences East China Normal University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yu","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Xu","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Gan","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liang","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxi","family":"Fang","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiai","family":"Shen","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhai","family":"Huang","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Hong","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Ma","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianqun","family":"Wu","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences East China Normal University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1373-7637","authenticated-orcid":false,"given":"Chen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye &amp; ENT Hospital Fudan University  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases NHC  Shanghai China"},{"name":"Key laboratory of Myopia and Related Eye Diseases Chinese Academy of Medical Sciences  Shanghai China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration  Shanghai China"},{"name":"Xiamen Eye Center of Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010024\u201001016\u20105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13524"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1217253"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2023.10.018"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad213"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2023.12.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1062045"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2022.101620"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac045"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010022\u201001518\u20108"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010020\u201000656\u2010y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309915"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.023"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20109139\u20106_2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051502"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202500029"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4PY00234B"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3209"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C0OB00355G"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2010.04.007"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00258E"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00766"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201501461"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4053"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29204818"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201045254\u20107"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.01.152"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c09649"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c21\u201001024"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.1c00046"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582\u20104934.2007.00167.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(18)53212\u20109"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.04.081"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3MH00717K"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1143157"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0088"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.226"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010020\u201001287\u2010y"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614949"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910434"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2022.02.015"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018\u201000272"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab824"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3117"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421\u2010019\u20100088\u20108"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba7365"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.06.027"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/372143a0"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar6245"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1481"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109394(14)72787\u20104"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102265.1997.2331047.x"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201021\u20100479"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100699"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9206297"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2023.341558"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1304"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw561"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu048"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3284"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.101088"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101746.2004.03183.x"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202511078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202511078","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202511078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:44:18Z","timestamp":1783115058000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202511078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,4]]},"references-count":62,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/adma.202511078"],"URL":"https:\/\/doi.org\/10.1002\/adma.202511078","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,4]]},"assertion":[{"value":"2025-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e11078"}}