{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:37:37Z","timestamp":1792183057297,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"43","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Immune\u2010checkpoint inhibitors (ICIs) have transformed the treatment of bladder cancer. However, inadequate immune responses restrict their clinical application. To increase the efficacy of ICIs, a nanozyme\u2010based intelligent biomimetic immune organelle has been developed for the treatment of metastatic bladder tumors. Initially, a reactive oxygen species (ROS)\u2010responsive nanozyme platform is constructed using 1,2\u2010Distearoyl\u2010sn\u2010glycero\u20103\u2010phosphoethanolamine\u2010Tk\u2010(polyethylene glycol) (DSPE\u2010TK\u2010PEG)\u00a0to assemble ultrasmall p\u2010d orbital hybrid bimetallic rhenium (Re)\u2010palladium (Pd) nanozyme. The orbital hybridization between the Re and Pd atoms significantly enhances the peroxidase (POD)\u2010like activity of the Pd nanozyme. Additionally, the RePd nanozyme exhibits notable glutathione oxidase (GSH\u2010OXD)\u2010like activity, which reduces the clearance of ROS and enhances its capacity to induce oxidative stress. This platform is then coated with bacterial outer membrane vesicles (OMVs) engineered with PD\u2010L1 nanobody (nb), which form RePd@OMVs\n                    <jats:sup>PD\u2010L1 nb<\/jats:sup>\n                    . Upon entry into the tumor microenvironment, the RePd nanozyme is released, and the PD\u2010L1 nb specifically binds to the tumor cell membrane to relieve its inhibition of T cells. Moreover, RePd@OMVs\n                    <jats:sup>PD\u2010L1 nb<\/jats:sup>\n                    demonstrates enhanced tumor accumulation and promotes synergistic catalytic\u2012photothermal therapy, inducing immunogenic cell death and promoting immune activation through the release of adjuvants. Consequently, the efficacy of PD\u2010L1 nb is significantly improved, leading to the effective eradication of tumor cells and the inhibition of recurrence and metastasis.\n                  <\/jats:p>","DOI":"10.1002\/adma.202511181","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T13:41:16Z","timestamp":1755178876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Nanozyme\u2010Based Biomimetic Intelligent Immune Organelles for the Treatment of Bladder\u2010Metastasized Tumors"],"prefix":"10.1002","volume":"37","author":[{"given":"Yalong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Urology China\u2010Japan Union Hospital of Jilin University Changchun Jilin 130033 P. R. 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