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In this study, we engineered pyroelectric nanostructure coatings on titanium (Ti) implants to enhance implant osteointegration through temperature fluctuation\u2010driven electrical stimulation. The pyroelectric titanium (pyroTi) implants leverage the combined effects of the pyroelectric effect and cold stimulation to amplify calcium ion (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) influx by activating cold\u2010sensitive transient receptor potential melastatin 8 (TRPM8) ion channel, therefore driving osteogenic differentiation of bone marrow\u2010derived mesenchymal stem cells (BMSCs). As a demonstration, pyroTi used\u00a0as a dental implant in the rabbit maxilla showed enhanced osteointegration under routine cold\u2010water intake. This study establishes a proof of concept for pyroelectric biomaterials that harness physiological temperature variations to potentiate bone\u2010implant integration.\n                  <\/jats:p>","DOI":"10.1002\/adma.202511334","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:05:10Z","timestamp":1773302710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cold\u2010Induced Pyroelectric Stimulation Enhances Implant Osteointegration via TRPM8 Activation"],"prefix":"10.1002","volume":"38","author":[{"given":"Kai","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biomaterials\/Periodontology School and Hospital of Stomatology Cheeloo College of Medicine Shandong University &amp; Shandong Key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical 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