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Herein, near\u2010infrared (NIR)\u2010responsive nanomotors are constructed by integrating thylakoid and platelet membranes on strontium\u2010doped mesoporous polydopamine nanoparticles (PSr@PT NPs), which enables synchronized thrombus dissolution and vascular microenvironment restoration. Following intravenous administration, PSr@PT nanomotors exhibited preferential accumulation within thrombi and were internalized by injured endothelial cells. Meanwhile, thylakoid\u2010embedded catalase catalyzed endogenous hydrogen peroxide to oxygen, which can not only suppress oxidative damage and neutralize to disrupt platelet\u2010endothelium interactions, but also generate self\u2010propulsive forces via gas propulsion, facilitating deep intrathrombus penetration of PSr@PT NPs. Proteomic analysis revealed that PSr@PT NPs inhibited thrombosis progression by downregulating platelet activation and modulating JAK\u2010STAT\/PI3K\u2010Akt signaling pathways, thereby reducing inflammation and fostering angiogenesis. Local NIR irradiation induced mild photothermal conversion of PSr@PT NPs, which softened fibrin networks, enhanced intrathrombus infiltration, and accelerated localized thrombolysis. In both FeCl\n                    <jats:sub>3<\/jats:sub>\n                    \u2010induced murine carotid thrombosis and arachidonic acid\u2010induced zebrafish thrombosis models, the PSr@PT NPs effectively resolved occlusions and restored endothelial function. By coupling ROS\u2010powered propulsion with adaptive microenvironment remodeling, this nanomotor transcends conventional 1D clot lysis, offering a dynamic strategy to prevent thrombosis recurrence and accelerate functional vascular recovery.\n                  <\/jats:p>","DOI":"10.1002\/adma.202511733","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T11:03:33Z","timestamp":1759575813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["NIR\u2010Driven Nanomotors Integrating With Platelet\u2010Thylakoid Hybrid Membranes for Synchronized Thrombolysis and Vascular Remodeling"],"prefix":"10.1002","volume":"38","author":[{"given":"Yuping","family":"Jiang","sequence":"first","affiliation":[{"name":"Key Laboratory of Marine Drugs Ministry of Education School of Medicine and Pharmacy Ocean University of China  Qingdao Shandong 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Ministry of Education School of Medicine and Pharmacy Ocean University of China  Qingdao Shandong 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Ministry of Education School of Medicine and Pharmacy Ocean University of China  Qingdao Shandong 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Ministry of Education School of Medicine and Pharmacy Ocean University of China  Qingdao Shandong 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Ministry of Education School of Medicine and Pharmacy Ocean University of China  Qingdao Shandong 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chensong","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Ministry of Education School of Medicine and Pharmacy Ocean University of China  Qingdao Shandong 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Ministry of Education School of Medicine and Pharmacy Ocean University of China  Qingdao Shandong 266003 China"},{"name":"Laboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology Center  Qingdao Shandong 266237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilu","family":"Yang","sequence":"additional","affiliation":[{"name":"Dongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine The Tenth Affiliated Hospital of Southern Medical University  Dongguan Guangdong 523059 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanbin","family":"Shen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Ministry of Education School of Medicine and Pharmacy Ocean University of China  Qingdao Shandong 266003 China"},{"name":"Laboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology Center  Qingdao Shandong 266237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1581-4691","authenticated-orcid":false,"given":"Lu","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Ministry of Education School of Medicine and Pharmacy Ocean University of China  Qingdao Shandong 266003 China"},{"name":"Laboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology Center  Qingdao Shandong 266237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae666.3187"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf117"},{"key":"e_1_2_8_3_1","first-page":"2936","volume":"45","author":"Damigou E.","year":"2024","journal-title":"Eur. 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