{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:02:16Z","timestamp":1790254936571,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"39","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170488"],"award-info":[{"award-number":["82170488"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2522021"],"award-info":[{"award-number":["T2522021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472153"],"award-info":[{"award-number":["82472153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Abdominal aortic aneurysm (AAA) is a fatal cardiovascular disease with hidden onset and high risk of rupture death, which is a major public health concern worldwide. Notably, aortic adventitia is the earliest lesions and the last barrier to rupture, and adventitial fibroblasts (AFs) are the key cellular components of aortic adventitia. Current treatments mainly focus on surgical resection with prosthetic graft replacement and endovascular stent grafting, yet failed to reconstruct the adventitia and abdominal aorta's natural structure effectively. In this study, we proposed an extravascular synergistic cocktail (ESC) therapeutic strategy to treat AAA by incorporating mechanical supporting and vascular remodeling inhibition based on a self\u2010healing bioelastomer with antifibrotic drug of lanifibranor. The single\u2010cell RNA\u2010sequencing revealed potential myogenic transformation of AFs in AAA with the release of chemokines like\n                    <jats:italic>monocyte chemoattractant protein\u20101 (MCP\u20101)<\/jats:italic>\n                    . The underlying mechanism of lanifibranor in maintaining the phenotype of AFs via promoting lipid metabolism was disclosed. The bioelastomer with multiple reversible dynamic bonds exhibits remarkable arterial\u2010like mechanical properties and ultra\u2010fast self\u2010healing ability under blood condition, and enables rapid in situ AAA wrapping treatment. In both the rat and dog AAA models, it has been fully demonstrated that the ESC therapy can provide effective mechanical support to prevent vascular dilation while continuously releasing lanifibranor to regulate myogenic transformation of AFs to inhibit the development of AAA. Additionally, we investigated the feasibility of minimally invasive laparoscopic implantation in bama pigs, emphasizing its potential for clinical translation and application.\n                  <\/jats:p>","DOI":"10.1002\/adma.202511786","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:34:07Z","timestamp":1774852447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Extravascular Synergistic Cocktail Therapeutic Strategy Based on Lanifibranor Loaded Self\u2010Healing Bioelastomer for Abdominal Aortic Aneurysms"],"prefix":"10.1002","volume":"38","author":[{"given":"Jiateng","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery Shanghai Key Lab of Tissue Engineering Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Vascular Centre of Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wufei","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Key Lab of Tissue Engineering Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Department of Medicine 1 Universit\u00e4tsklinikum Erlangen Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijue","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Systems Biomedicine (Ministry of Education) Shanghai Center for Systems Biomedicine Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenghui","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Key Lab of Tissue Engineering Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengshi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Key Lab of Tissue Engineering Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Vascular Centre of Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Key Lab of Tissue Engineering Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Vascular Centre of Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingqi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Key Lab of Tissue Engineering Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Biological Science and Medical Engineering Donghua University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2488-2733","authenticated-orcid":false,"given":"Guangdong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Key Lab of Tissue Engineering Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Shandong Provincial Key Laboratory For Tissue Regeneration and Repair &amp; Reconstruction (Under Preparation) Research Institute of Plastic Surgery Shandong Second Medical University  Weifang Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Key Lab of Tissue Engineering Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shanghai Key Lab of Tissue Engineering Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"},{"name":"Vascular Centre of Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010018\u20100030\u20107"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.18638"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044803"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.04.066"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2023.08.027"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.154"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2020.11.037"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad386"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010018\u20100114\u20109"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102257"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adh1763"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201024680\u2010x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.171488"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.06.023"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70159"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.270520"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X211021170"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309859"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000246113.82111.2d"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201010839\u20100"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107791"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010023\u201001180\u20102"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006537\u2010z"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2036205"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.027"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.045"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.025"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102015\u2010208029"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.04.049"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11375"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303577"},{"key":"e_1_2_9_34_1","first-page":"1071","article-title":"Targeting HSP90 attenuates angiotensin II\u2010induced adventitial remodelling via suppression of mitochondrial fission","volume":"116","author":"Huang G.","year":"2020","journal-title":"Cardiovascular Research"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010020\u201000372\u20107"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108436"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010022\u201000778\u20100"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201049921\u20107"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.066110"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.09.004"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa319"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211314"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201029137\u20103"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.07.027"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab788"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421\u2010022\u201000388\u20100"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.06.037"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.10.066"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.70008"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010022\u201003037\u20101"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1958"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.208"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c00120"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz303"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14442"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202405761"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adp4726"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050389\u20108"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2022.09.010"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.31123"},{"key":"e_1_2_9_61_1","article-title":"Laparoscopic Surgery for Elective Abdominal Aortic Aneurysm Repair","volume":"5","author":"Robertson L.","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2022.06.018"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2021.02.035"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2020.09.044"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(04)16979\u20101"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)31135\u20107"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2016.02.021"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202511786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202511786","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202511786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:11:36Z","timestamp":1790251896000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202511786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,29]]},"references-count":66,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/adma.202511786"],"URL":"https:\/\/doi.org\/10.1002\/adma.202511786","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,29]]},"assertion":[{"value":"2025-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e11786"}}