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Inspired by the marine mussel\n                    <jats:italic>Mytilus edulis<\/jats:italic>\n                    foot protein (Mefp), a pH\u2010responsive multifunctional bone glue (YDC\u2010Gel\u2010Zn) with broad\u2010spectrum adhesion capabilities is developed for osteoporotic bone\u2010implant integration. This pseudo\u2010Mefp bioglue enables dual\u2010interface adhesion via catechol\u2010rich sequences that mediate stable metal\u2010phenolic coordination with metallic implants and hydrogen\u2010bonded\/Michael addition\u2010driven interactions with the bone matrix, thereby improving initial implant fixation. Under osteoporotic inflammatory microenvironments, sequential dissociation of borate ester bonds and metal\u2012phenolic coordination facilitates the controlled release of Zn\n                    <jats:sup>2<\/jats:sup>\n                    \u207a and proangiogenic\/osteogenic peptides (YDC). The released Zn\n                    <jats:sup>2<\/jats:sup>\n                    \u207a remodels glutathione metabolism through glutathione S\u2010transferase (GST)\u2010mediated regulation of glutathione (GSH) levels, inhibits JAK1\/STAT1\/NLRP3 inflammasome activation, and suppresses the release of proinflammatory cytokines from senescent M1 macrophages, recalibrating the osteo\u2010vascular\u2010immune microenvironment. Due to its positive effects on bone regeneration and angiogenesis, the bioinspired bone bioglue demonstrated a 194% increase in fixation strength in osteoporotic rat models, achieving 93% healthy bone\u2010implant stability. Overall, this study provides a clinically translatable strategy for stable implantation under osteoporotic conditions through synergistic mechanical adaptation, bioactivity regulation, and smart environmental responsiveness.\n                  <\/jats:p>","DOI":"10.1002\/adma.202511840","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:36:18Z","timestamp":1762353378000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A Pseudo\u2010\n                    <i>Mytilus Edulis<\/i>\n                    Foot Protein\u2010Based Hydrogel Adhesive with Osteo\u2010Vascular\u2010Immune Coupling Effects for Osteoporotic Bone\u2010Implant Integration"],"prefix":"10.1002","volume":"38","author":[{"given":"Wentao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopedics Centre for Leading Medicine and Advanced Technologies of IHM The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230022 P. 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