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However, their therapeutic efficacy against IBD is hindered by poor homing capacity and excessive leukocyte infiltration at inflamed colonic sites. In this study, MSCs with a Y\u2010shaped bispecific antibody (YMV) assembled via DNA nanotechnology, which integrates anti\u2010vascular cell adhesion molecule\u20101 (anti\u2010VCAM\u20101) and anti\u2010mucosal addressing cell adhesion molecules\u20101 (anti\u2010MAdCAM\u20101) antibodies are engineered, to enhance targeted delivery and inhibit leukocyte recruitment. YMV\u2010modified MSCs show an approximately threefold enhancement in adhesion efficiency compared with native MSCs. Notably, they effectively compete for MAdCAM\u20101 binding sites and significantly suppress leukocyte adhesion. In a mouse model of IBD, YMV\u2010MSCs demonstrate enhanced homing to the colon, promote mucosal repair, reduce leukocyte infiltration, and attenuate local inflammation. This DNA\u2010mediated bispecific antibody modification strategy improves MSCs targeting and exerts anti\u2010inflammatory effects by blocking leukocyte recruitment, offering a promising platform for MSC\u2010based therapy.<\/jats:p>","DOI":"10.1002\/adma.202511854","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T12:46:35Z","timestamp":1760445995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["DNA\u2010Scaffolded Bispecific Antibodies Enhance Mesenchymal Stromal Cell Therapy for Inflammatory Bowel Disease"],"prefix":"10.1002","volume":"38","author":[{"given":"Xi","family":"Liu","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences and Engineering, Guangzhou International Campus South China University of Technology  Guangzhou 511442 P. R. 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