{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:19:56Z","timestamp":1792207196427,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"45","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2321004,52202351"],"award-info":[{"award-number":["T2321004,52202351"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022ZD20"],"award-info":[{"award-number":["ZR2022ZD20"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Central nervous system (CNS) injury is one of the most serious public health problems worldwide. To prevent secondary cascade damages to CNS caused by dural defects, the repair of dural defects is an essential step in CNS injury treatment. Although various artificial dura maters have been developed, unfortunately, no one exerting positive therapeutic effects for CNS injury repair. Here, we suggested a flexible \u201cliving\u201d artificial dura mater as a general strategy for CNS injury treatment by integrating the neural stem cells (NSCs) therapy and electrical stimulation. Under a rotating magnetic field based on magnetoelectric induction, NSCs seeded on a specially designed flexible patch with Au nanostrips produced therapeutic benefits to CNS injury. In vitro experiments prove that the magnetic field\u2010driven Au nanostrips\u2010mediated wireless electrical stimulation not only effectively accelerates NSCs differentiating into mature neurons with complex synaptic connections, but also induces astrocytes directionally activating into neuroprotective A2 reactive astrocytes. In vivo experiments with traumatic brain or spinal cord injury models confirm that the flexible living artificial dura mater shows optimal interface integration with tissue, effectively improving the immune microenvironment of the defect site, promoting the survival and differentiation of NSCs, and aiding the recovery of motor neural circuits after injury.<\/jats:p>","DOI":"10.1002\/adma.202511878","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T08:02:42Z","timestamp":1756454562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Flexible Living Artificial Dura Mater for Efficient Therapy of Central Nervous System Injury Based on Neuronal Differentiation and Neuroprotective A2 Astrocyte Activation"],"prefix":"10.1002","volume":"37","author":[{"given":"Hongru","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crystal Materials Shandong University  Jinan Shandong 250100 China"},{"name":"Department of Materials Science and Engineering Johns Hopkins University  Baltimore MD 21218 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crystal Materials Shandong University  Jinan Shandong 250100 China"},{"name":"Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 China"},{"name":"Department of Oral and Maxillofacial Surgery Qilu Hospital of Shandong University  Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengming","family":"Lou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crystal Materials Shandong University  Jinan Shandong 250100 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