{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:48:43Z","timestamp":1791002923082,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110162"],"award-info":[{"award-number":["2023A1515110162"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M723024"],"award-info":[{"award-number":["2022M723024"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52273197"],"award-info":[{"award-number":["52273197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22505210"],"award-info":[{"award-number":["22505210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52333007"],"award-info":[{"award-number":["52333007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB3810001"],"award-info":[{"award-number":["2023YFB3810001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pulmonary embolism (PE), a life\u2010threatening condition caused by thromboembolic obstruction of pulmonary arteries, demands urgent therapeutic interventions and precise diagnostic strategies to prevent systemic complications. Current thrombolytic therapies and imaging modalities face critical limitations, including hemorrhagic risks from high\u2010dose fibrinolytic drugs and insufficient sensitivity for detecting microemboli or dynamically tracking thrombolytic progression. Herein, a self\u2010propelling nanomotor platform is reported that integrates second near\u2010infrared window (NIR\u2010II) fluorescence imaging\u2010guided navigation, thrombus\u2010targeting capability, and synergistic thrombolysis for real\u2010time theranostics management of PE. Leveraging a relatively high fluorescence quantum yield (1.08%) for NIR\u2010II probes and prolonged circulation half\u2010life (7.2 h), these nanomotors enable sensitive detection of submillimeter microemboli and sustained, millimeter\u2010level precision monitoring of thrombolytic progression. Through a self\u2010penetration\u2010enhanced synergistic therapy\u2010 combining thermal ablation and chemical lysis, the platform achieved rapid vascular recanalization, exceeding 95% efficiency within a shortened therapeutic timeframe, using only 13.6% of the clinical urokinase (UK) dose. Validation in both the posterior auricular artery thrombosis (PAAT) and submillimeter microemboli\u2010induced PE models demonstrated accelerated embolus clearance, precision thrombolytic monitoring, and excellent biosafety without secondary embolism or hemorrhagic complications. This work demonstrates the significant potential of multifunctional nanomotors for the precision management of thrombotic disorders.<\/jats:p>","DOI":"10.1002\/adma.202512075","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T11:46:11Z","timestamp":1757677571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["NIR\u2010II Imaging\u2010Guided Self\u2010Penetrating Nanomotors for Millimeter\u2010Scale Deep Thrombolysis Tracking and Accelerated Embolus Clearance"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5917-8183","authenticated-orcid":false,"given":"Mengli","family":"Liu","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital, School of Medicine The Chinese University of Hong Kong, Shenzhen &amp; Longgang District People's Hospital of Shenzhen  Guangdong 518172 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Jining NO.1 People's Hospital  Shandong 272000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7533-0686","authenticated-orcid":false,"given":"Bin Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong  Shenzhen Guangdong 518172 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Soochow University  Jiangsu 215006 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulong","family":"Ma","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong  Shenzhen Guangdong 518172 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Luo","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Medicine The Chinese University of Hong Kong, Shenzhen &amp; Longgang District People's Hospital of Shenzhen  Guangdong 518172 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Medicine The Chinese University of Hong Kong, Shenzhen &amp; Longgang District People's Hospital of Shenzhen  Guangdong 518172 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvej","family":"Alam","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Medicine The Chinese University of Hong Kong, Shenzhen &amp; Longgang District People's Hospital of Shenzhen  Guangdong 518172 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben Zhong","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong  Shenzhen Guangdong 518172 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-0439","authenticated-orcid":false,"given":"Zheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, School of Medicine The Chinese University of Hong Kong, Shenzhen &amp; Longgang District People's Hospital of Shenzhen  Guangdong 518172 P. R. China"},{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong  Shenzhen Guangdong 518172 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1217815"},{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.3.707"},{"key":"e_1_2_7_1_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2015.11.026"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00876-0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102171"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz9014"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202409176"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-35895-5"},{"key":"e_1_2_7_4_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0061-0"},{"key":"e_1_2_7_4_4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202425189"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202578"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c09986"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0118-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b00594"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106994"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42691-8"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.77"},{"key":"e_1_2_7_8_3","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.104"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-11812-6"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/2396987320966420"},{"key":"e_1_2_7_9_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.042"},{"key":"e_1_2_7_9_4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.19.2321"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b09277"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2993"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwad286"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b14343"},{"key":"e_1_2_7_11_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0494-0"},{"key":"e_1_2_7_11_4","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.458"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00001H"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c06061"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004208"},{"key":"e_1_2_7_13_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c06965"},{"key":"e_1_2_7_13_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16924-z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.708"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.352"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201602052"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cs15113d"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202417440"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49217-w"},{"key":"e_1_2_7_17_3","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c12219"},{"key":"e_1_2_7_17_4","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b00902"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c11749"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c05128"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901378"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121426"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202104264"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201603463"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-024-01826-y"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60721-0"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c07280"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202425189"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk8970"},{"key":"e_1_2_7_25_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010025\u201000818\u2010x"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202512075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T06:30:49Z","timestamp":1767421849000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202512075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,12]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/adma.202512075"],"URL":"https:\/\/doi.org\/10.1002\/adma.202512075","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2025-nlw3n","asserted-by":"object"}]},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,12]]},"assertion":[{"value":"2025-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12075"}}