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The formation of the fibrin network is the initial stage of wound control. Inspired by Fn's characteristics during coagulation, an artificial polycationic fibroin (pCSF\/\u03b2) is designed to achieve hemostasis\u2010regeneration transition. pCSF\/\u03b2 replicates the aggregation state and maturation process of Fn through intermolecular interaction and subsequent strain hardening originating from ethanol\u2010inducing \u03b2\u2010sheet to recapitulate natural coagulation networks, achieving mechanical reinforcement and shape recovery. Proteomics and transcriptomics analyses reveal that pCSF\/\u03b2 connects hemostasis and regeneration through platelet contents\u2019 release and the PI3K\/Akt signaling pathway. The results of incompressible hemostasis, large\u2010area skin repair, and penetrating liver regeneration in animal models such as minipigs confirm pCSF\/\u03b2 is superior to clinical products in rapid hemostasis and synchronous tissue regeneration. The molecular design of pCSF\/\u03b2 provides new insights for developing biomaterials in rapid hemostasis and simultaneous regeneration.<\/jats:p>","DOI":"10.1002\/adma.202512265","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T06:32:47Z","timestamp":1756794767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A Shape\u2010Recovery Polycationic Fibroin for Hemostasis\u2010Regeneration Transition by Recapitulating Natural Coagulation Networks"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6947-2761","authenticated-orcid":false,"given":"Yuxiang","family":"Wang","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Biomaterials Sichuan University  29# Wangjiang Road Chengdu Sichuan 610064 China"},{"name":"College of Biomedical Engineering Sichuan University  29# Wangjiang Road Chengdu Sichuan 610064 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