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This study presents a high\u2010performance thermoelectric catalytic therapy (TECT) utilizing Cu self\u2010doped Cu\n                    <jats:sub>2+x<\/jats:sub>\n                    Zn\n                    <jats:sub>1\u2010x<\/jats:sub>\n                    SnSe\n                    <jats:sub>4<\/jats:sub>\n                    nanosheets synthesized with non\u2010stoichiometric ratios modified with DSPE\u2010mPEG\n                    <jats:sub>2000<\/jats:sub>\n                    (n\u2010CZTSe@PEG NSs). Under 808 nm laser irradiation, n\u2010CZTSe@PEG NSs demonstrate an impressive photothermal conversion efficiency of 47.62%, rapidly establishing a significant local temperature gradient. This increase in temperature initiates thermoelectric catalysis (TEC), effectively generating reactive oxygen species (ROS) that are toxic to cancer cells. The thermoelectric figure of merit\n                    <jats:italic>ZT<\/jats:italic>\n                    of n\u2010CZTSe@PEG NSs at room temperature is observed to be 45.45% higher than that of pure phase CZTSe. Experimental results, supported by density functional theory calculations, reveal that lattice disorder and the presence of highly degenerate electronic bands at the band edges decouple thermal and electrical transport, enhancing the TEC effect. The additional copper ions at zinc sites increase carrier concentration, hole conductivity, and peroxidase\u2010like activity, thereby enhancing ROS production, depleting glutathione, accelerating lipid peroxidation, and inhibiting glutathione peroxidase 4, ultimately inducing ferroptosis in cancer cells. Consequently, a synergistic TECT and ferroptosis effect is achieved, resulting in significant anti\u2010cancer efficacy.\n                  <\/jats:p>","DOI":"10.1002\/adma.202512426","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T07:36:41Z","timestamp":1756539401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Self\u2010Doped Cu\n                    <sub>2+x<\/sub>\n                    Zn\n                    <sub>1\u2010x<\/sub>\n                    SnSe\n                    <sub>4<\/sub>\n                    Nanosheets for Enhanced Thermoelectric Catalytic\u2010Ferroptotic Therapy"],"prefix":"10.1002","volume":"37","author":[{"given":"Siyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Zang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shili","family":"Gai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. 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