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In this work, two poly(ethylene glycol)\u2010functionalized rhombic dodecahedral tetradecanuclear metal\u2010imidazolate cages (denoted as\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2)<\/jats:bold>\n                    are reported, modified with diethylene glycol (PEG\n                    <jats:sub>2<\/jats:sub>\n                    ) and triethylene glycol (PEG\n                    <jats:sub>3<\/jats:sub>\n                    ) chains, respectively. Both cages are liquids at room temperature and are obtained via subcomponent self\u2010assembly of 4\u2010methyl\u20105\u2010imidazolecarboxaldehyde, Ni\n                    <jats:sup>2+<\/jats:sup>\n                    , and NH\n                    <jats:sub>2<\/jats:sub>\n                    \u2010PEG\n                    <jats:sub>2<\/jats:sub>\n                    or NH\n                    <jats:sub>2<\/jats:sub>\n                    \u2010PEG\n                    <jats:sub>3<\/jats:sub>\n                    . Both ionic PLs demonstrate higher nitric oxide (NO) adsorption capacities than their solid\u2010state counterparts, with\n                    <jats:bold>1<\/jats:bold>\n                    showing the highest performance, capturing approximately eight NO molecules per cage. Upon aqueous stimulation, the cages rapidly release NO, effectively killing\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . To achieve sustained NO release, cage\n                    <jats:bold>1<\/jats:bold>\n                    is incorporated into a sodium alginate (SA) hydrogel composite (\n                    <jats:bold>1<\/jats:bold>\n                    @SA), which exhibits prolonged antibacterial activity while promoting angiogenesis and modulating inflammation in vitro. NO\u2010loaded hydrogel films (NO@\n                    <jats:bold>1<\/jats:bold>\n                    @SA) are fabricated, demonstrating accelerated burn wound healing through slow NO release, which enhances angiogenesis while providing anti\u2010inflammatory and antibacterial effects. This work not only demonstrates the high potential of metal\u2010imidazolate cage\u2010based PLs as exogenous NO delivery platforms but also paves the way for biomedical applications of porous liquids.\n                  <\/jats:p>","DOI":"10.1002\/adma.202512460","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T16:34:15Z","timestamp":1760373255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Metal\u2010Imidazolate Cages as Porous Ionic Liquids: A Nitric Oxide Delivery Therapeutic Platform for Burn Wound Healing"],"prefix":"10.1002","volume":"38","author":[{"given":"Hao\u2010Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University  Guangzhou Guangdong 510632 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Feng","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Engineering Research Center of Artificial Organs and Materials Jinan University  Guangzhou 510632 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Shuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Engineering Research Center of Artificial Organs and Materials Jinan University  Guangzhou 510632 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang\u2010Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University  Guangzhou Guangdong 510632 P. R. 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