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Although various biomaterials have been developed, current strategies often fail to address the combined obstacles of immune dysregulation, oxidative damage, and bone loss. An injectable multifunctional hydrogel (HTF@HA) with a dynamic borate ester cross\u2010linked network is designed to provide environmental responsiveness and temporal release of bioactive factors. Under acidic and oxidative conditions, the hydrogel degrades more rapidly and preferentially releases antioxidative and anti\u2010inflammatory components, facilitating macrophage polarization toward the M2 phenotype and alleviating inflammation. During the subsequent repair phase, calcium\u2010phosphate interactions mediate the sustained release of concentrated growth factors (CGF) and low\u2010dose bone morphogenetic protein\u20102 (BMP\u20102), supporting osteogenic differentiation and angiogenesis. In vitro, HTF@HA exhibits high biocompatibility, antioxidative capacity, anti\u2010inflammatory effects, and significant enhancement of periodontal ligament stem cell osteogenesis and endothelial cell angiogenesis under inflammatory conditions. Animal studies confirm that the hydrogel promoted new bone and vessel formation (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), and at a BMP\u20102 dose of 50\u00a0\u00b5g\/L, it achieved bone regeneration comparable to high\u2010dose BMP\u20102 (500\u00a0\u00b5g\/L,\n                    <jats:italic>p<\/jats:italic>\n                    &gt; 0.05). Overall, HTF@HA provides a promising injectable biomaterial with \u201canti\u2010inflammatory\u2010antioxidant\u2010regenerative\u201d synergy for treating inflammation\u2010associated periodontal bone defects.\n                  <\/jats:p>","DOI":"10.1002\/adma.202512531","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T10:56:10Z","timestamp":1759575370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Environmental Response Temporal Release Injectable Hydrogel for Controlled Growth Factor Release to Enhance Inflammatory Periodontal Bone Defect Regeneration"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-3532","authenticated-orcid":false,"given":"Piaopiao","family":"Qiu","sequence":"first","affiliation":[{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration &amp; Tongji Research Institute of 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