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Moreover, suboptimal drug delivery to the bone marrow, combined with the protective effects of the niche that shelters residual leukemia cells, frequently underlies chemotherapy failure and relapse. Here, a neutrophil\/leukemia\u2010tropic polymersome vincristine\/volasertib dual\u2010drug nanoformulation (NLP\u2010Vi\/Vo) is reported to selectively bind to leukemia cells and neutrophils, and to ratiometrically release clinical chemotherapeutics and a polo\u2010like kinase 1 inhibitor, thereby potentiating the treatment of AML. NLP\u2010Vi\/Vo induces synergistic anti\u2010AML effects by sensitizing AML to chemotherapy, and homes to bone marrow by hitchhiking on neutrophils, cooperatively depleting leukemia in both the bloodstream and bone marrow. NLP\u2010Vi\/Vo shows excellent therapeutic efficacy in malignant murine AML and human AML xenograft models. Collectively, neutrophil\/leukemia\u2010directing dual\u2010drug nanomedicines offer a promising treatment strategy for AML.<\/jats:p>","DOI":"10.1002\/adma.202512635","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T10:36:15Z","timestamp":1762770975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neutrophil\/Leukemia\u2010Tropic Dual\u2010Drug Nanomedicine Potentiates the Treatment of Acute Myeloid Leukemia"],"prefix":"10.1002","volume":"38","author":[{"given":"Shujing","family":"Yue","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioinspired Interfacial Materials Science and Biomedical Polymers Laboratory College of Chemistry Chemical Engineering and Materials Science Soochow University  Suzhou 215123 P. R. 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