{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:46:29Z","timestamp":1792122389671,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Secondary traumatic brain injury (TBI) induces a pro\u2010inflammatory microenvironment that hampers neural stem cells (NSCs) therapy and tissue regeneration. To address this challenge, an immuno\u2010piezoelectric transducer have been developed to create an anti\u2010inflammatory immune microenvironment, deliver wireless electrical stimulation, and facilitate multimodal NSCs therapy. The immuno\u2010piezoelectric transducer drives the polarization of microglia towards the anti\u2010inflammatory M2 phenotype and secretion of anti\u2010inflammatory cytokines. This modulation significantly reduces the inflammatory response, creating an optimal microenvironment for NSCs survival. Furthermore, the wireless electrical stimulation generated by ultrasound facilitates NSCs differentiation into glutamatergic and GABAergic neurons, enhances neurite complexity, upregulates synaptic proteins expression and neural integration in injured regions. The multimodal therapy demonstrates superior outcomes in restoring structural integrity, improving functional, and enhancing behavioral action in TBI rat models. This study integrates piezoelectric with immunomodulation to reprogram the neuroimmune microenvironment, providing novel therapeutic paradigm for brain injury repair.<\/jats:p>","DOI":"10.1002\/adma.202512810","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T08:19:34Z","timestamp":1759306774000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neuroimmune Microenvironment Reprogramming via Immuno\u2010piezoelectric Transducers for Synergistic Stem Cell Therapy in Traumatic Brain Injury"],"prefix":"10.1002","volume":"38","author":[{"given":"Linlin","family":"Liang","sequence":"first","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences  27 Taiping Rd Beijing 100850 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences  27 Taiping Rd Beijing 100850 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Hu","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine Southern Medical University  Guangzhou Guangdong 510515 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingqiang","family":"Cai","sequence":"additional","affiliation":[{"name":"Digital Molecular Analytics and Science (IDMxS) Nanyang Technological University  59 Nanyang Drive Singapore 636921 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwu","family":"Wang","sequence":"additional","affiliation":[{"name":"Digital Molecular Analytics and Science (IDMxS) Nanyang Technological University  59 Nanyang Drive Singapore 636921 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Digital Molecular Analytics and Science (IDMxS) Nanyang Technological University  59 Nanyang Drive Singapore 636921 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences  27 Taiping Rd Beijing 100850 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences  27 Taiping Rd Beijing 100850 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changgeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences  27 Taiping Rd Beijing 100850 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences  27 Taiping Rd Beijing 100850 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crystal Materials Shandong University  27 Shandanan Road Jinan Shandong 250100 P. R. China"},{"name":"Institute for Advanced Interdisciplinary Research University of Jinan  Jinan Shandong 250022 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyong","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences  27 Taiping Rd Beijing 100850 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3128-407X","authenticated-orcid":false,"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Institute of Basic Medical Sciences  27 Taiping Rd Beijing 100850 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.22"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01199-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301738"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32912-x"},{"key":"e_1_2_8_5_1","first-page":"1990","volume":"18","author":"Liu X. Y.","year":"2023","journal-title":"Neural Regener. Res."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304284"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003909117"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51098-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00572C"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121310"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adj1946"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.12087"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0487-x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.12020"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106317"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06732-y"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abk0159"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-024-01798-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00965-4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c10227"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2012.69"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b11697"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1602165"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC06909H"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c05818"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cs00108b"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.09.001"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202006093"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12545-3"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007550"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-022-00383-2"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b05075"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6260"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-020-0518-9"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43070-z"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202417869"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100505"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b02081"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200462883"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202101033"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05300"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102981"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2017.03.001"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj4260"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202206779"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c07973"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012079"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-025-02214-w"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.04.021"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198110293051806"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.12006"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.8b01799"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202512810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202512810","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202512810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:27:52Z","timestamp":1775917672000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202512810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/adma.202512810"],"URL":"https:\/\/doi.org\/10.1002\/adma.202512810","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"assertion":[{"value":"2025-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12810"}}