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Formulating drugs directly into robust DMNs is further challenged by crystallization tendencies. Here, a supramolecular engineering strategy enabling carrier\u2010free antibiotic glass microneedles (GMNs) is presented, leveraging synergistic drug\u2010sulfate\u2010water interactions that suppress crystallization and form mechanically stable amorphous networks. Using tobramycin sulfate, monolithic GMNs are achieved with 100%\u2010drug payload, exceptional strength (Young's modulus 5.1\u00a0GPa), and instant transdermal delivery (threefold faster than polymer DMNs). Eliminating polymeric carriers accelerates drug diffusion by 2.6\u2010fold, enabling deep tissue penetration for efficient biofilm eradication. In vivo evaluation demonstrates that the antibiotic GMNs effectively promote the healing of biofilm\u2010infected skin wounds in mice and exhibit potent therapeutic efficacy against subcutaneous abscesses. This strategy extends broadly to aminoglycoside antibiotics. By replacing the polymer matrix with supramolecular\u2010engineered amorphous networks, a next\u2010generation DMN platform is pioneered that bridges critical gaps in drug\u2010loading efficiency, dissolution kinetics, and clinical translation for urgent therapeutic applications.<\/jats:p>","DOI":"10.1002\/adma.202512849","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T12:16:00Z","timestamp":1758111360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["All Drug Glassy Microneedle Patches for Instantaneous Transdermal Delivery"],"prefix":"10.1002","volume":"38","author":[{"given":"Qiang","family":"Chen","sequence":"first","affiliation":[{"name":"Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology (HUST)  Wuhan 430074 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